Geranylphenazinediol, an Acetylcholinesterase Inhibitor Produced by a Streptomyces Species

被引：44

作者：

Ohlendorf, Birgit ^{[1
]}

Schulz, Dirk ^{[1
]}

Erhard, Arlette ^{[1
]}

Nagel, Kerstin ^{[1
]}

Imhoff, Johannes F. ^{[1
]}

机构：

[1] Helmholtz Zenrum Ozeanforsch GEOMAR, Kiefer Wirkstoff Zentrum KiWiZ, D-24106 Kiel, Germany

来源：

JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 07期

关键词：

ENDOPHENAZINES A-D; PHENAZINE ANTIBIOTICS; BIOSYNTHESIS; FERMENTATION; TAXONOMY;

D O I：

10.1021/np2009626

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Geranylphenazinediol (1), a new phenazine natural product, was produced by the Streptomyces sp. strain LB 173, which was isolated from a marine sediment sample. The structure was established by analysis of NMR and MS data 1 inhibited the enzyme acetylcholinesterase in the low micromolar range and showed weak antibacterial activity. In order to get a more detailed picture of the activity profile of 1, its inhibitory potential was compared to that of related structures.

引用

页码：1400 / 1404

页数：5

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