3-[(3'-hydroxymethyl)-4'-hydroxybutyl]imidazo[4,5-b]pyridines - Novel antiviral agents

被引：28
|
作者：
Cundy, DJ
Holan, G
Otaegui, M
Simpson, GW
机构：
[1] CSIRO: Div. of Chemical and Polymers, South Clayton MDC, Clayton, Vic. 3122
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 06期
关键词：
D O I：
10.1016/S0960-894X(97)00082-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Derivatives of 3- and 1-(4'-hydroxy-3'-(hydroxymethyl)butyl)-imidazo[4,5-b]pyridine were prepared in several steps from 2-amino-5-chloropyridine. Selected compounds were evaluated against human cytomeglovirus (HCMV), herpes simplex virusus (HSV1/HSV2) and varicella tester virus (VZV). Details of their synthesis and biological activities are presented. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：669 / 674
页数：6
相关论文
共 50 条
  • [41] Efficient synthesis of 3H-imidazo[4,5-b]pyridines from malononitrile and 5-amino-4-(cyanoformimidoyl)imidazoles
    Zaki, MEA
    Proença, MF
    Booth, BL
    JOURNAL OF ORGANIC CHEMISTRY, 2003, 68 (02): : 276 - 282
  • [42] Solubility, UV/Vis, and fluoresence study of various 2-aryl-3H-imidazo[4,5-b]pyridines
    Podgurski, Amanda
    Haddad, Samantha
    Bernard, Kennedy
    Mulligan, Rose
    Murray, James
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 255
  • [43] Synthesis and evaluation of the solvatochromic properties of various 2,6-diaryl-3H-imidazo[4,5-b]pyridines
    Murray, James
    Castaldi, Michael
    Bauman, Mercedes
    Ragheb, Susan
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
  • [44] Effect of aryl and N-heterocyclic systems on the solvatochromatic properties of 3H-imidazo[4,5-b]pyridines
    Bauman, Mercedes
    Ross, Patrick
    Ragheb, Susan
    Castaldi, Michael
    Murray, James
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252
  • [45] Direct Alkynylation of 3H-Imidazo[4,5-b]pyridines Using gem-Dibromoalkenes as Alkynes Source
    Aziz, Jessy
    Baladi, Tom
    Piguel, Sandrine
    JOURNAL OF ORGANIC CHEMISTRY, 2016, 81 (10): : 4122 - 4133
  • [46] Imidazo[4,5-b]Pyridines: From Kinase Inhibitors to more Diversified Biological Properties
    Jarmoni, Karim
    Misbahi, Khalid
    Ferrieres, Vincent
    CURRENT MEDICINAL CHEMISTRY, 2024, 31 (05) : 515 - 528
  • [47] Synthesis of Substituted Imidazo[1,5-a]pyrimidines, 1H-pyrrolo[2,3-b] pyridines and 3-methyl-3H-imidazo[4,5-b]pyridines
    Wu, Jingshing
    Xing, Xuechao
    Cuny, Gregory D.
    LETTERS IN ORGANIC CHEMISTRY, 2009, 6 (03) : 203 - 207
  • [48] 2-[(ACYLAMINO)METHYL]-6-METHYLPYRIMIDIN-4(3H)-ONES - NOVEL PRECURSORS FOR THE SYNTHESIS OF IMIDAZO[1,5-A]PYRIMIDINES AND IMIDAZO[4,5-B]PYRIDINES
    KATAGIRI, N
    KOSHIHARA, A
    ATSUUMI, S
    KATO, T
    JOURNAL OF ORGANIC CHEMISTRY, 1982, 47 (01): : 167 - 169
  • [49] SYNTHESIS OF IMIDAZO[4,5-B]PYRAZINE NUCLEOSIDES
    PANZICA, RP
    TOWNSEND, LB
    JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1973, (03): : 244 - 248
  • [50] Synthesis of thienoimidazo[4,5-b]pyridines and thenylidenoimidazolinones
    Björk, M
    Grivas, S
    HETEROCYCLES, 2005, 65 (10) : 2369 - 2380
12345