3-[(3'-hydroxymethyl)-4'-hydroxybutyl]imidazo[4,5-b]pyridines - Novel antiviral agents

被引：28
|
作者：
Cundy, DJ
Holan, G
Otaegui, M
Simpson, GW
机构：
[1] CSIRO: Div. of Chemical and Polymers, South Clayton MDC, Clayton, Vic. 3122
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 06期
关键词：
D O I：
10.1016/S0960-894X(97)00082-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Derivatives of 3- and 1-(4'-hydroxy-3'-(hydroxymethyl)butyl)-imidazo[4,5-b]pyridine were prepared in several steps from 2-amino-5-chloropyridine. Selected compounds were evaluated against human cytomeglovirus (HCMV), herpes simplex virusus (HSV1/HSV2) and varicella tester virus (VZV). Details of their synthesis and biological activities are presented. (C) 1997 Elsevier Science Ltd.
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页码：669 / 674
页数：6
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