Inhibitors of sterol biosynthesis as Staphylococcus aureus antibiotics

被引:15
作者
Walsh, Christopher T. [1 ]
Fischbach, Michael A. [1 ]
机构
[1] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA
关键词
antibiotics; biosynthesis; carotenoids; enzymes; inhibitors;
D O I
10.1002/anie.200801801
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:5700 / 5702
页数:3
相关论文
共 14 条
[1]   Staphyloxanthin plays a role in the fitness of Staphylococcus aureus and its ability to cope with oxidative stress [J].
Clauditz, Alexandra ;
Resch, Alexandra ;
Wieland, Karsten-Peter ;
Peschel, Andreas ;
Goetz, Friedrich .
INFECTION AND IMMUNITY, 2006, 74 (08) :4950-4953
[2]  
Committee on New Directions in the Study of Antimicrobial Therapeutics: New Classes of Antimicrobials
[3]  
Committee on New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation
[4]  
Board on Life Sciences
[5]  
Division on Earth and Life Studies
[6]  
National Research Council, 2006, TREAT INF DIS MICR W
[7]   Emerging options for treatment of invasive, multidrug-resistant Staphylococcus aureus infections [J].
Drew, Richard H. .
PHARMACOTHERAPY, 2007, 27 (02) :227-249
[8]   Sterols and isoprenoids: Signaling molecules derived from the cholesterol biosynthetic pathway [J].
Edwards, PA ;
Ericsson, J .
ANNUAL REVIEW OF BIOCHEMISTRY, 1999, 68 :157-185
[9]   Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization [J].
Hung, DT ;
Shakhnovich, EA ;
Pierson, E ;
Mekalanos, JJ .
SCIENCE, 2005, 310 (5748) :670-674
[10]   Invasive methicillin-resistant Staphylococcus aureus infections in the United States [J].
Klevens, R. Monina ;
Morrison, Melissa A. ;
Nadle, Joelle ;
Petit, Susan ;
Gershman, Ken ;
Ray, Susan ;
Harrison, Lee H. ;
Lynfield, Ruth ;
Dumyati, Ghinwa ;
Townes, John M. ;
Craig, Allen S. ;
Zell, Elizabeth R. ;
Fosheim, Gregory E. ;
McDougal, Linda K. ;
Carey, Roberta B. ;
Fridkin, Scott K. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 298 (15) :1763-1771