Synthesis and biological evaluation of 4-(2′,4′-difluorobiphenyl-4-yl)-6-arylpyrimidin-2-amine derivatives

被引：0

作者：

Fathimunnisa, M. ^{[1
]}

Manikandan, Haridoss ^{[1
]}

Neelakandan, K. ^{[1
]}

Prasad, N. Rajendra ^{[2
]}

Ganesan, M. ^{[2
]}

机构：

[1] Annamalai Univ, Dept Chem, Annamalainagar 608002, Tamil Nadu, India

[2] Annamalai Univ, Dept Biochem & Biotechnol, Annamalainagar 608002, Tamil Nadu, India

来源：

HETEROCYCLIC COMMUNICATIONS | 2016年 / 22卷 / 06期

关键词：

antimicrobial activity; cytotoxic activity; molecular docking; MTT assay; MEDICINAL CHEMISTRY; MOLECULAR DOCKING; ANTIBACTERIAL; ANTICANCER; AGENTS; CHALCONES; FLUORINE;

D O I：

10.1515/hc-2016-0050

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-(2', 4'-Difluorobiphenyl-4-yl)-6-arylpyrimidin-2-amines 5a-g were synthesized and evaluated for their ability to inhibit various bacterial and fungal strains. The cytotoxicity of the compounds was investigated by a 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay against the Hep-2 cell line. Molecular docking studies were also conducted to locate the binding interaction with the target protein 4LRH.

引用

页码：351 / 356

页数：6

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