Metal-based new sulfonamides: Design, synthesis, antibacterial, antifungal, and cytotoxic properties

被引:31
作者
Chohan, Zahid H. [1 ]
Shad, Hazoor A. [1 ]
机构
[1] Bahauddin Zakariya Univ, Dept Chem, Multan 60800, Pakistan
关键词
Sulfonamides; metal(II) complexes; antibacterial; antifungal; cytotoxic; IN-VITRO ANTIBACTERIAL; SCHIFF-BASES; ZINC(II) COMPLEXES; COPPER(II) COMPLEXES; BIOLOGICAL-PROPERTIES; NICKEL(II); COBALT(II); LIGANDS; NI(II); CU(II);
D O I
10.3109/14756366.2011.593515
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cobalt(II), copper(II), nickel(II) and zinc(II) metal complexes with 5-chlorosalicyladehyde derived Schiff base sulfonamides have been synthesized and characterized. Structure and bonding nature of all the synthesized compounds have been deduced from physical, analytical, and spectral (IR, H-1 NMR, C-13 NMR, Mass, electronic) data. An octahedral geometry has been proposed for all the metal complexes. The ligands and their metal complexes have been screened for their in vitro antibacterial, antifungal, and cytotoxic properties and results are reported.
引用
收藏
页码:403 / 412
页数:10
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