Synthesis of New Functionalized 1,4-Dihydroquinolines and Pyrimido[4,5-b]quinolines

被引：6

作者：

Khoramdelan, F. ^{[1
]}

Davoodnia, A. ^{[1
]}

Bozorgmehr, M. R. ^{[1
]}

Ebrahimi, M. ^{[1
]}

机构：

[1] Islamic Azad Univ, Mashhad Branch, Dept Chem, Mashhad 9175687119, Iran

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2017年 / 87卷 / 12期

关键词：

dihydroquinoline; pyrimido[4,5-b]quinoline; POCl3; carboxylic acids; ONE-POT SYNTHESIS; MICROWAVE-ASSISTED SYNTHESIS; QUINOLINE DERIVATIVES; ANTIVIRAL ACTIVITY; ANTIOXIDANT; ULTRASOUND; GLYCOSIDES; FACILE;

D O I：

10.1134/S1070363217120386

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reaction of N-alkylisatoic anhydrides with malononitrile in pyridine led to formation of new 2-amino-1-alkyl-4-oxo-1,4-dihydroquinoline-3-carbonitriles. Following treatment of these compounds with an excess of aliphatic carboxylic acids in the presence of POCl3 under reflux gave novel 2,10-dialkylpyrimido[4,5-b]quinoline-4,5(3H,10H)-diones with high yields. It is probable that synthesis of the latter products proceed via the tandem intramolecular Pinner-Dimroth rearrangement. All synthesized compounds were characterized by spectral and microanalytical data.

引用

页码：2961 / 2965

页数：5

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