Measurement and correlation of solubility and dissolution properties of flunixin meglumine in pure and binary solvents

被引：38

作者：

Qin, Yujia ^{[1
,2
]}

Wang, Haisheng ^{[1
,2
]}

Yang, Peng ^{[1
,2
]}

Du, Shichao ^{[1
,2
]}

Huang, Cui ^{[1
,2
]}

Du, Yanni ^{[1
,2
]}

Wu, Songgu ^{[1
,2
]}

Gong, Junbo ^{[1
,2
]}

Yin, Qiuxiang ^{[1
,2
]}

机构：

[1] Tianjin Univ, State Key Lab Chem Engn, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China

[2] Coinnovat Ctr Chem & Chem Engn Tianjin, Tianjin 300072, Peoples R China

来源：

FLUID PHASE EQUILIBRIA | 2015年 / 403卷

基金：

中国国家自然科学基金;

关键词：

Flunixin meglumine; Solubility; Dielectric constant; Thermodynamic properties; DIELECTRIC-CONSTANTS; ETHANOL; WATER; PARAMETERS; MIXTURES; ACID;

D O I：

10.1016/j.fluid.2015.06.026

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

The solubility of flunixin meglumine (FM) in six pure solvents and binary solvents of ethanol + isopropanol was measured over the temperature ranged from 28315 K to 328.15 K by using a static gravimetric method. It is positively correlated with temperature and negatively correlated with the molar fraction of isopropanol. The modified Apelblat equation was used to correlate the experimental solubility in pure solvents. Dissolution properties based on the modified Apelblat equation were calculated and discussed. The solubility in binary solvents at various temperatures was well correlated by the nearly ideal binary solvent (NIBS)/Redlich-Kister model. In addition, in order to correlate the solubility to both the composition and temperature in mixed solvents, a new model related to dielectric constant was proposed. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：145 / 152

页数：8

共 27 条

[1] MATHEMATICAL REPRESENTATION OF THERMODYNAMIC PROPERTIES .2. DERIVATION OF THE COMBINED NEARLY IDEAL BINARY SOLVENT (NIBS) REDLICH-KISTER MATHEMATICAL REPRESENTATION FROM A 2-BODY AND 3-BODY INTERACTIONAL MIXING MODEL [J].