Medical evaluation of the effectiveness and outcome of regional anesthesia in burn populations to reduce drug use: a systematic review and meta-analysis

The results of regional anesthesia (RA) techniques on pain relief and narcotic consumption are challenging and should be evaluated. Hence, the purpose of the present article was to evaluate the efficacy and outcome of RA in adult patients with burns to decrease narcotic consumption and pain. The initial search was performed by two blind and independent browsers in electronic databases (PubMed, Cochrane Library, and Embase) until May 2021. For data analysis, after extracting the data of three studies that met the inclusion criteria, the mean and risk difference methods were used with a 95% confidence interval, the fixed-effect model and the Mantel-Haenszel/inverse variance method were used were calculated for the data. Stata software version 16, a faster version of Stata, was used for statistical analysis. 24 articles were found in the initial review, the abstracts reviewed by two blind and independent authors. Finally, after reviewing the full text of 9 articles, 3 articles were selected. The mean difference of cumulative Morphine requirements was 49.01 (MD, -49.01 95% CI 56.36, -41.67. P-VALUE=0.00) between continuous RA and control group of cumulative Morphine requirements. Meta-analysis showed that both RA had statically significantly lower total morphine consumption than the control group. Meta-analysis showed RA reduced total morphine consumption and pain.