How Biofilm Growth AffectsCandida-Host Interactions

被引:56
作者
Eix, Emily F.
Nett, Jeniel E. [1 ]
机构
[1] Univ Wisconsin, Dept Med, Madison, WI 53706 USA
基金
美国国家卫生研究院;
关键词
Candida; biofilm; host; neutrophil; macrophage; matrix; immunity; dispersion; NEUTROPHIL EXTRACELLULAR TRAPS; CANDIDA-ALBICANS BIOFILMS; ANTIFUNGAL ACTIVITY; MURINE MODEL; INVASIVE CANDIDIASIS; AMPHOTERICIN-B; EXPRESSION; PARAPSILOSIS; INFECTIONS; TROPICALIS;
D O I
10.3389/fmicb.2020.01437
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Candidaspp. proliferate as surface-associated biofilms in a variety of clinical niches. These biofilms can be extremely difficult to eradicate in healthcare settings. Cells within biofilm communities grow as aggregates and produce a protective extracellular matrix, properties that impact the ability of the host to respond to infection. Cells that disperse from biofilms display a phenotype of enhanced pathogenicity. In this review, we highlight host-biofilm interactions forCandida, focusing on how biofilm formation influences innate immune responses.
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页数:8
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