Alkali-free bioactive glasses for bone tissue engineering: A preliminary investigation

被引：94

作者：

Goel, Ashutosh ^{[1
]}

Kapoor, Saurabh ^{[2
]}

Rajagopal, Raghu Raman ^{[2
]}

Pascual, Maria J. ^{[3
]}

Kim, Hae-Won ^{[4
,5
,6
]}

Ferreira, Jose M. F. ^{[2
]}

机构：

[1] Pacific NW Natl Lab, Richland, WA 99354 USA

[2] Univ Aveiro, CICECO, Dept Ceram & Glass Engn, P-3810193 Aveiro, Portugal

[3] CSIC, Inst Ceram & Vidrio, E-28049 Madrid, Spain

[4] Dankook Univ, Dept Nanobiomed Sci, Cheonan 330714, South Korea

[5] Dankook Univ, WCU Res Ctr, Cheonan 330714, South Korea

[6] Dankook Univ, Inst Tissue Regenerat Engn ITREN, Cheonan 330714, South Korea

来源：

ACTA BIOMATERIALIA | 2012年 / 8卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Bioactive glass; Scaffolds; Glass-ceramic; Sintering; Alkaline phosphate activity; IN-VITRO; MECHANICAL-PROPERTIES; CERAMICS; BEHAVIOR; CRYSTALLIZATION; BIOCERAMICS; DIOPSIDE; SURFACE; DESIGN; NMR;

D O I：

10.1016/j.actbio.2011.08.026

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

An alkali-free series of bioactive glasses has been designed and developed in the glass system CaO-MgO-SiO2-P2O5-CaF2 along the diopside (CaMgSi2O6)-fluorapatite (Ca-5(PO4)(3)F)-tricalcium phosphate (3CaO center dot P2O5) join. The silicate network in all the investigated glasses is predominantly coordinated in Q(2) (Si) units, while phosphorus tends to remain in an orthophosphate (Q(0)) environment. The in vitro bioactivity analysis of glasses has been made by immersion of glass powders in simulated body fluid (SBF) while chemical degradation has been studied in Tris-HCl in accordance with ISO-10993-14. Some of the investigated glasses exhibit hydroxyapatite formation on their surface within 1-12 h of their immersion in SBF solution. The sintering and crystallization kinetics of glasses has been investigated by differential thermal analysis and hot-stage microscopy, respectively while the crystalline phase evolution in resultant glass-ceramics has been studied in the temperature range of 800-900 degrees C using powder X-ray diffraction and scanning electron microscopy. The alkaline phosphatase activity and osteogenic differentiation for glasses have been studied in vitro on sintered glass powder compacts using rat bone marrow mesenchymal stem cells. The as-designed glasses are ideal candidates for their potential applications in bone tissue engineering in the form of bioactive glasses as well as glass/glass-ceramic scaffolds. Published by Elsevier Ltd. on behalf of Acta Materialia Inc.

引用

页码：361 / 372

页数：12

共 42 条

[41] Antimicrobial effect of nanometric bioactive glass 45S5 [J].