CRIF1 overexpression facilitates tumor growth and metastasis through inducing ROS/NFκB pathway in hepatocellular carcinoma

被引：35

作者：

Chang, Hulin ^{[1
,2
]}

Li, Juntang ^{[3
,4
]}

Qu, Kai ^{[1
]}

Wan, Yong ^{[1
]}

Liu, Sinan ^{[1
]}

Zheng, Wei ^{[2
]}

Zhang, Zhiyong ^{[2
]}

Liu, Chang ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Coll Med, Dept Hepatobiliary Surg, Xian 710061, Shaanxi, Peoples R China

[2] Xi An Jiao Tong Univ, Affiliated Hosp 3, Coll Med, Dept Hepatobiliary Surg, Xian 710068, Shaanxi, Peoples R China

[3] Anal Colorectal Surg Inst PLA, Ctr Inflammat & Canc Res, Luoyang 471031, Henan, Peoples R China

[4] 150th Cent Hosp PLA, Dept Pathol, Luoyang 471031, Henan, Peoples R China

来源：

CELL DEATH & DISEASE | 2020年 / 11卷 / 05期

基金：

中国国家自然科学基金;

关键词：

MITOCHONDRIAL; CANCER; PHOSPHORYLATION; METABOLISM; BCL-2;

D O I：

10.1038/s41419-020-2528-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

CR6-interacting factor 1 (Crif1) is a mitochondrial protein which is required for the assembly of oxidative phosphorylation (OXPHOS) complexes. Our bioinformatics analysis based on Cancer Genome Atlas (TCGA) database revealed an aberrant overexpression of CRIF1 in hepatocellular carcinoma (HCC). However, the clinical significance and biological functions of CRIF1 are still unclear in this malignancy. Here, we report that CRIF1 is frequently overexpressed in HCC cells mainly due to the downregulation of miR-497-5p, which is associated with poor prognosis of patients with HCC. CRIF1-promoted HCC growth and metastasis by suppressing cell apoptosis and inducing cell cycle progression and epithelial to mesenchymal transition (EMT). Mechanistically, increased mitochondrial ROS production and consequently activation of the NF kappa B signaling pathway was found to be involved in the promotion of growth and metastasis by CRIF1 in HCC cells. In summary, CRIF1 plays an oncogenic role in HCC progression through activating ROS/NFKB pathway, implying CRIF1 as a potential prognostic factor and therapeutic target in HCC.

引用

页数：13

共 50 条

[21] Thioredoxin facilitates hepatocellular carcinoma stemness and metastasis by increasing BACH1 stability to activate the AKT/mTOR pathway [J].

Wang, Chengmeng ;

Zhang, Lu ;

Cao, Manqing ;

Fu, Zhou ;

Wang, Huaqi ;

Zhang, Su ;

Zhu, Keyun ;

Hou, Zhenyu ;

Cui, Jinfang ;

Yue, Ping ;

Guo, Hua ;

Zhang, Ti .

FASEB JOURNAL, 2023, 37 (06)

[22] Tim-3 facilitates osteosarcoma proliferation and metastasis through the NF-κB pathway and epithelial-mesenchymal transition [J].

Feng, Z. M. ;

Guo, S. M. .

GENETICS AND MOLECULAR RESEARCH, 2016, 15 (03)

[23] CADM2, as a new target of miR-10b, promotes tumor metastasis through FAK/AKT pathway in hepatocellular carcinoma [J].

Li, Dongliang ;

Zhang, Yongjian ;

Zhang, He ;

Zhan, Chao ;

Li, Xin ;

Ba, Tu ;

Qiu, Zini ;

Fang, E. ;

Lv, Guixiang ;

Zou, Chendan ;

Wang, Chuxuan ;

Si, Lining ;

Zou, Chaoxia ;

Li, Qiang ;

Gao, Xu .

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2018, 37

[24] Morin inhibits colorectal tumor growth through inhibition of NF-κB signaling pathway [J].

Chen, Rui ;

Zhang, Li .

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2019, 41 (06) :622-629

[25] Asperulosidic Acid Restrains Hepatocellular Carcinoma Development and Enhances Chemosensitivity Through Inactivating the MEKK1/NF-κB Pathway [J].

Li, Liang ;

Qiu, Huiwen .

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2024, 196 (01) :1-17

[26] PIGU promotes hepatocellular carcinoma progression through activating NF-κB pathway and increasing immune escape [J].

Wei, Xin ;

Yang, Wenjie ;

Zhang, Feng ;

Cheng, Feng ;

Rao, Jianhua ;

Lu, Ling .

LIFE SCIENCES, 2020, 260

[27] MicroRNA-29-3p Regulates Hepatocellular Carcinoma Progression Through NF-κB Pathway [J].

Ma, Ji-Hong ;

Bu, Xuan ;

Wang, Jian-Jun ;

Xie, Yu-Xi .

CLINICAL LABORATORY, 2019, 65 (05) :801-806

[28] The mechanism of miR-143 inducing apoptosis of liver carcinoma cells through regulation of the NF-κB pathway [J].

Zheng, Yi ;

Yang, Fan ;

Fu, Ling ;

Liu, Kang .

ONCOLOGY LETTERS, 2018, 15 (06) :9567-9571

[29] Hinokiflavone induces apoptosis via activating mitochondrial ROS/JNK/caspase pathway and inhibiting NF-κB activity in hepatocellular carcinoma [J].

Mu, Wan ;

Cheng, Xuefang ;

Zhang, Xue ;

Liu, Ying ;

Lv, Qianzhou ;

Liu, Gaolin ;

Zhang, Jigang ;

Li, Xiaoyu .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2020, 24 (14) :8151-8165

[30] Overexpression of HDAC6 suppresses tumor cell proliferation and metastasis by inhibition of the canonical Wnt/β-catenin signaling pathway in hepatocellular carcinoma [J].

Yin, Zhusheng ;

Xu, Wei ;

Xu, Hao ;

Zheng, Junnian ;

Gu, Yuming .

ONCOLOGY LETTERS, 2018, 16 (06) :7082-7090

← 1 2 3 4 5 →