Longitudinal Changes in Disc and Retinal Lesions Among Highly Myopic Adolescents in Singapore Over a 10-Year Period

被引:23
作者
Wong, Yee-Ling [1 ,2 ]
Ding, Yang [3 ,4 ]
Sabanayagam, Charumathi [4 ,5 ,6 ]
Wong, Chee-Wai [4 ,6 ]
Verkicharla, Pavan [4 ]
Ohno-Matsui, Kyoko [7 ]
Tan, Donald [4 ,5 ,6 ]
Yeo, Anna Chwee-Hong [2 ]
Hoang, Quan V. [4 ,6 ,8 ]
Lamoureux, Ecosse [4 ,6 ]
Saw, Seang-Mei [1 ,4 ,5 ,6 ]
机构
[1] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore
[2] Essilor Inc Corp, R&D AMERA, Vis Sci, Singapore, Singapore
[3] Wenzhou Med Coll, Sch Optometry & Ophthalmol, Wenzhou, Peoples R China
[4] Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore
[5] Natl Univ Hlth Syst, Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore, Singapore
[6] Natl Univ Singapore, Duke NUS Grad Med Sch, Singapore, Singapore
[7] Tokyo Med & Dent Univ, Dept Ophthalmol & Visual Sci, Tokyo, Japan
[8] Columbia Univ Coll Phys & Surg, Edward S Harkness Eye Inst, Dept Ophthalmol, 630 W 168th St, New York, NY 10032 USA
来源
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE | 2018年 / 44卷 / 05期
基金
英国医学研究理事会;
关键词
Longitudinal changes; Myopic macular degeneration; Disc and retinal lesions; Choroidal thickness; High myopia; OPTIC DISC; PATHOLOGICAL MYOPIA; RISK-FACTORS; PREVALENCE; PROGRESSION; RETINOPATHY; CHILDREN; ADULTS;
D O I
10.1097/ICL.0000000000000466
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Objectives: To examine the progression pattern of disc and retinal lesions in highly myopic Chinese adolescents over a 10-year period in Singapore. Methods: This longitudinal study included Chinese participants who showed high myopia (spherical equivalent [SE] worse than or equal to 25 diopters [D]), no history of refractive surgery, and available fundus photographs at both 2006 (baseline) and 2016 (10-year follow-up) visits. Forty-four adolescents (aged 12-16 years at baseline) who were reexamined later at follow-up were included. Cycloplegic refraction, biometry, and fundus photography were performed at both visits. A trained grader classified myopic macular degeneration (MMD) based on the Meta-pathologic myopia classification and disc lesions from fundus photographs. Choroidal thickness (CT) measurements were performed at 10-year follow-up using swept-source optical coherence tomography. The ocular parameters and lesions were compared between baseline and follow-up. Results: There was a significant worsening of high myopia at follow-up to 27.5 +/- 1.8 D (mean SE +/- SD) in 2016 versus 26.2 +/- 1.3 D in 2006; (P < 0.001). The 10-year changes included increased degree of tessellation (26 eyes, 29.5%), development of new tessellated fundus (19 eyes, 21.6%), disc tilt (7 eyes, 8.0%), and expansion of peripapillary atrophy size (33 eyes, 37.5%). Eyes with early-onset tessellation (present at baseline, 48 eyes) showed significantly thinner CT (P < 0.05), compared with eyes with late-onset tessellation (incident at 10-year follow-up, 19 eyes). No cases of MMD were recorded at baseline or 10-year follow-up. Conclusions: Although there was no incident MMD, the retinal and disc lesions worsened over the follow-up period. Early-onset fundus tessellation was associated with thinner CT.
引用
收藏
页码:286 / 291
页数:6
相关论文
共 25 条
[11]   Pathologic Myopia [J].
Ohno-Matsui, Kyoko .
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY, 2016, 5 (06) :415-423
[12]   International Photographic Classification and Grading System for Myopic Maculopathy [J].
Ohno-Matsui, Kyoko ;
Kawasaki, Ryo ;
Jonas, Jost B. ;
Cheung, Chui Ming Gemmy ;
Saw, Seang-Mei ;
Verhoeven, Virginie J. M. ;
Klaver, Caroline C. W. ;
Moriyama, Muka ;
Shinohara, Kosei ;
Kawasaki, Yumiko ;
Yamazaki, Mai ;
Meuer, Stacy ;
Ishibashi, Tatsuro ;
Yasuda, Miho ;
Yamashita, Hidetoshi ;
Sugano, Akira ;
Wang, Jie Jin ;
Mitchell, Paul ;
Wong, Tien Yin .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 2015, 159 (05) :877-883
[13]   Worldwide prevalence and risk factors for myopia [J].
Pan, Chen-Wei ;
Ramamurthy, Dharani ;
Saw, Seang-Mei .
OPHTHALMIC AND PHYSIOLOGICAL OPTICS, 2012, 32 (01) :3-16
[14]   Myopia-Related Optic Disc and Retinal Changes in Adolescent Children from Singapore [J].
Samarawickrama, Chameen ;
Mitchell, Paul ;
Tong, Louis ;
Gazzard, Gus ;
Lim, Laurence ;
Wong, Tien-Yin ;
Saw, Seang-Mei .
OPHTHALMOLOGY, 2011, 118 (10) :2050-2057
[15]   A cohort study of incident myopia in Singaporean children [J].
Saw, SM ;
Shankar, A ;
Tan, SB ;
Taylor, H ;
Tan, DTH ;
Stone, RA ;
Wong, TY .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2006, 47 (05) :1839-1844
[16]   Incidence and progression of myopia in Singaporean school children [J].
Saw, SM ;
Tong, L ;
Chua, WH ;
Koh, D ;
Tan, DTH ;
Katz, J .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2005, 46 (01) :51-57
[17]  
Tokoro T., 2012, Atlas of posterior fundus changes in pathologic myopia
[18]   Prevalence and progression of myopic retinopathy in an older population [J].
Vongphanit, J ;
Mitchell, P ;
Wang, JJ .
OPHTHALMOLOGY, 2002, 109 (04) :704-711
[19]   A note on robust variance estimation for cluster-correlated data [J].
Williams, RL .
BIOMETRICS, 2000, 56 (02) :645-646
[20]   Is Choroidal or Scleral Thickness Related to Myopic Macular Degeneration? [J].
Wong, Chee Wai ;
Phua, Val ;
Lee, Shu Yen ;
Wong, Tien Yin ;
Cheung, Chui Ming Gemmy .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2017, 58 (02) :907-913