Cannabis sativa research trends, challenges, and new-age perspectives

被引：46

作者：

Hussain, Tajammul ^{[1
]}

Jeena, Ganga ^{[1
]}

Pitakbut, Thanet ^{[1
]}

Vasilev, Nikolay ^{[1
]}

Kayser, Oliver ^{[1
]}

机构：

[1] TU Dortmund Univ, Dept Tech Biochem, Emil Figge Str 66, D-44227 Dortmund, Germany

来源：

ISCIENCE | 2021年 / 24卷 / 12期

关键词：

NITROGEN-FERTILIZATION; GLANDULAR TRICHOMES; POLYKETIDE SYNTHASE; HEMP; TEMPERATURE; IDENTIFICATION; BIOSYNTHESIS; ACCUMULATION; EXPRESSION; TOLERANCE;

D O I：

10.1016/j.isci.2021.103391

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cannabis sativa L. has been one of the oldest medicinal plants cultivated for 10,000 years for several agricultural and industrial applications. However, the plant became controversial owing to some psychoactive components that have adverse effects on human health. In this review, we analyzed the trends in cannabis research for the past two centuries. We discussed the historical transitions of cannabis from the category of herbal medicine to an illicit drug and back to a medicinal product post-legalization. In addition, we address the newage application of immuno-suppressive and anti-inflammatory extracts for the treatment of COVID-19 inflammation. We further address the influence of the legal aspects of cannabis cultivation for medicinal, pharmaceutical, and biotechnological research. We reviewed the up-to-date cannabis genomic resources and advanced technologies for their potential application in genomic-based cannabis improvement. Overall, this review discusses the diverse aspects of cannabis research developments ranging from traditional use as herbal medicine to the latest potential in COVID-19, legal practices with updated patent status, and current state of art genetic and genomic tools reshaping cannabis biotechnology in modern age agriculture and pharmaceutical industry.

引用

页数：13

共 107 条

[31] Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides [J].

Gagne, Steve J. ;

Stout, Jake M. ;

Liu, Enwu ;

Boubakir, Zakia ;

Clark, Shawn M. ;

Page, Jonathan E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (31) :12811-12816

[32] A high-quality reference genome of wild Cannabis sativa [J].

Gao Shan ;

Wang Baishi ;

Xie Shanshan ;

Xu Xiaoyu ;

Zhang Jin ;

Pei Li ;

Yu Yongyi ;

Yang Weifei ;

Zhang Ying .

HORTICULTURE RESEARCH, 2020, 7 (01)

[33] CANNABICHROMENE A NEW ACTIVE PRINCIPLE IN HASHISH [J].

GAONI, Y ;

MECHOULA.R .

CHEMICAL COMMUNICATIONS, 1966, (01) :20-&

[34] ISOLATION, STRUCTURE, AND PARTIAL SYNTHESIS OF AN ACTIVE CONSTITUENT OF HASHISH [J].

GAONI, Y ;

MECHOULAM, R .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (08) :1646-+

[35]

Gerra Gilberto, 2010, Recent Pat CNS Drug Discov, V5, P46

[36] THE CANNABIS CROP [J].

Gould, Julie .

NATURE, 2015, 525 (7570) :S2-S3

[37]

Grassa C.J., 2018, BioRxiv, P1, DOI DOI 10.1101/458083

[38] A new Cannabis genome assembly associates elevated cannabidiol (CBD) with hemp introgressed into marijuana [J].

Grassa, Christopher J. ;

Weiblen, George D. ;

Wenger, Jonathan P. ;

Dabney, Clemon ;

Poplawski, Shane G. ;

Timothy Motley, S. ;

Michael, Todd P. ;

Schwartz, C. J. .

NEW PHYTOLOGIST, 2021, 230 (04) :1665-1679

[39] Transcriptomic profiling of hemp bast fibres at different developmental stages [J].

Guerriero, Gea ;

Behr, Marc ;

Legay, Sylvain ;

Mangeot-Peter, Lauralie ;

Zorzan, Simone ;

Ghoniem, Mohammad ;

Hausman, Jean-Francois .

SCIENTIFIC REPORTS, 2017, 7

[40] MORPHOGENESIS OF CAPITATE GLANDULAR HAIRS OF CANNABIS-SATIVA (CANNABACEAE) [J].

HAMMOND, CT ;

MAHLBERG, PG .

AMERICAN JOURNAL OF BOTANY, 1977, 64 (08) :1023-1031

← 1 2 3 4 5 6 7 8 9 10 →