Serum testosterone levels in males with Alzheimer's disease

被引：30
作者：
Pennanen, C
Laakso, MP
Kivipelto, M
Ramberg, J
Soininen, H
机构：
[1] Kuopio Univ Hosp, Dept Neurol, Kuopio 70211, Finland
[2] Univ Kuopio, Dept Neurol & Neurosci, FIN-70211 Kuopio, Finland
[3] Kuopio Univ Hosp, Dept Clin Radiol, Kuopio 70211, Finland
[4] Orion Diagnost, Oulunsalo, Finland
来源：
JOURNAL OF NEUROENDOCRINOLOGY | 2004年 / 16卷 / 02期
关键词：
ageing; androgen; brain; dementia; hypogonadism;
D O I：
10.1111/j.0953-8194.2004.01133.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This study aimed to investigate whether there are differences in serum testosterone levels between male patients with Alzheimer's disease (AD) and cognitively normal male controls. Testosterone and sex hormone binding globulin (SHBG) levels were measured from 14 patients with mild to moderate AD and 16 age-matched control males. The AD patients had higher levels of serum total (P = 0.02) and free testosterone (P < 0.001), and higher free androgen index (FAI) (P = 0.02) compared to controls. No differences were found for the SHBG levels. These data provide no support for hypotheses of (disproportionally) decreased levels of serum testosterone in AD. These data also show that all cognitively normal controls had an FAI below the normal range.
引用
收藏
页码：95 / 98
页数：4
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