Hypothesis paper brain talks with fat -: evidence for a hypothalamic-pituitary-adipose axis?

被引：65
作者：
Schäffler, A
Binart, N
Schölmerich, J
Büchler, C
机构：
[1] Univ Regensburg, Dept Internal Med 1, D-93042 Regensburg, Germany
[2] Fac Med Necker Enfants Malad, INSERM U584, Paris, France
来源：
NEUROPEPTIDES | 2005年 / 39卷 / 04期
关键词：
pituitary; hypothalamus; adipocyte; hormone; receptor;
D O I：
10.1016/j.npep.2005.06.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The adipose tissue signals to the brain via its secretory products. However, it is unknown whether the brain itself can directly contact the fat tissue. In order to test this hypothesis, the adipocytic expression of receptors for pituitary hormones and hypothalamic peptides was investigated. Besides FSH- and LH-receptors, adipocytes do express the specific receptors for ACTH, TSH, GH, prolactin, oxytocin and the three receptor subtypes for vasopressin. Thus, the adipose tissue might no longer be regarded as an inert and steady tissue but as a fast acting player downstream of and under the control of the brain. Based on this, the potential existence and clinical impact of a hypothalamic pituitary-adipose axis should further be investigated. (c) 2005 Published by Elsevier Ltd.
引用
收藏
页码：363 / 367
页数：5
相关论文
共 11 条
  • [1] An update on the biology and physiology of resistin
    Adeghate, E
    [J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 2004, 61 (19-20) : 2485 - 2496
  • [2] Adaptations of Glucose Metabolism During Pregnancy and Lactation
    Bell, Alan W.
    Bauman, Dale E.
    [J]. JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 1997, 2 (03) : 265 - 278
  • [3] PITUITARY STIMULATION BY COMBINED ADMINISTRATION OF 4 HYPOTHALAMIC RELEASING HORMONES IN NORMAL MEN AND PATIENTS
    COHEN, R
    BOUQUIER, D
    BIOTLAPORTE, S
    VERMEULEN, E
    CLAUSTRAT, B
    CHERPIN, MH
    CABRERA, P
    GUIDETTI, P
    FERRY, S
    BIZOLLON, CA
    SASSOLAS, G
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1986, 62 (05) : 892 - 898
  • [4] Update on adipocyte hormones - Regulation of energy balance and carbohydrate/lipid metabolism
    Havel, PJ
    [J]. DIABETES, 2004, 53 : S143 - S151
  • [5] Prolactin enhances CCAAT enhancer-binding protein-β (C/EBPβ) and peroxisome proliferator-activated receptor γ (PPARγ) messenger RNA expression and stimulates adipogenic conversion of NIH-3T3 cells
    Nanbu-Wakao, R
    Fujitani, Y
    Masuho, Y
    Muramatu, M
    Wakao, H
    [J]. MOLECULAR ENDOCRINOLOGY, 2000, 14 (02) : 307 - 316
  • [6] Adiponectin acts in the brain to decrease body weight
    Qi, Y
    Takahashi, N
    Hileman, SM
    Patel, HR
    Berg, AH
    Pajvani, UB
    Scherer, PE
    Ahima, RS
    [J]. NATURE MEDICINE, 2004, 10 (05) : 524 - 529
  • [7] Minireview: The adipocyte - At the crossroads of energy homeostasis, inflammation, and atherosclerosis
    Rajala, MW
    Scherer, PE
    [J]. ENDOCRINOLOGY, 2003, 144 (09) : 3765 - 3773
  • [8] REINBERG A, 1982, ANN ENDOCRINOL-PARIS, V43, P309
  • [9] Mechanisms of disease:: adipocytokines and visceral adipose tissue-emerging role in intestinal and mesenteric diseases
    Schäffler, A
    Schölmerich, J
    Büchler, C
    [J]. NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY, 2005, 2 (02): : 103 - 111
  • [10] Prolactin potentiates insulin-stimulated leptin expression and release from differentiated brown adipocytes
    Viengchareun, S
    Bouzinba-Segard, H
    Laigneau, JP
    Zennaro, MC
    Kelly, PA
    Bado, A
    Lombès, M
    Binart, N
    [J]. JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2004, 33 (03) : 679 - 691
12