Hormonal and nutritional control of L-carnitine uptake in myoblastic C2C12 cells

被引：1

作者：

Le Borgne, Francoise ^{[1
]}

Rigault, Caroline ^{[1
]}

Georges, Beatrice ^{[1
]}

Demarquoy, Jean ^{[1
]}

机构：

[1] Univ Bourgogne, Fac Gabriel, Lab Biochim Metab & Nutr, INSERM,U866, F-21000 Dijon, France

来源：

MUSCLE & NERVE | 2008年 / 38卷 / 01期

关键词：

C2C12; insulin; iron; L-carnitine; T3;

D O I：

10.1002/mus.21008

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

L-Carnitine plays an important role in skeletal muscle bioenergetics, and its bioavailability and thus its import may be crucial for muscle function. We studied the effect of thyroid hormone, insulin, and iron overload, hormones and nutrients known to alter muscle metabolism, on over-load import into C2C12 cells. We report here L-carnitine uptake is increased by thyroid hormones and decreased by iron. Insulin was found to be ineffective in altering the L-carnitine uptake.

引用

页码：912 / 915

页数：4

共 21 条

[1] DEFECTS OF FATTY-ACID OXIDATION IN MUSCLE [J].

ANGELINI, C .

BAILLIERES CLINICAL ENDOCRINOLOGY AND METABOLISM, 1990, 4 (03) :561-582

[2] Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects [J].

Bandyopadhyay, Gautam K. ;

Yu, Joseph G. ;

Ofrecio, Jachelle ;

Olefsky, Jerrold M. .

DIABETES, 2006, 55 (08) :2277-2285

[3] Lipid metabolism, exercise and insulin action [J].

Bonen, Arend ;

Dohm, G. Lynis ;

van Loon, Luc J. C. .

ESSAYS IN BIOCHEMISTRY, VOL 42: THE BIOCHEMICAL BASIS OF THE HEALTH EFFECTS OF EXERCISE, 2006, 42 :47-59

[4]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P159

[5] Reduced exercise capacity in genetic haemochromatosis [J].

Davidsen, Einar Skulstad ;

Liseth, Knut ;

Omvik, Per ;

Hervig, Tor ;

Gerdts, Eva .

EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION, 2007, 14 (03) :470-475

[6] Radioisotopic determination of L-carnitine content in foods commonly eaten in Western countries [J].

Demarquoy, J ;

Georges, W ;

Rigault, C ;

Royer, MC ;

Clairet, A ;

Soty, M ;

Lekounoungou, S ;

Le Borgne, F .

FOOD CHEMISTRY, 2004, 86 (01) :137-142

[7] Thyroid hormone controls carnitine status through modifications of γ-butyrobetaine hydroxylase activity and gene expression [J].

Galland, S ;

Georges, B ;

Le Borgne, F ;

Conductier, G ;

Dias, JV ;

Demarquoy, J .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2002, 59 (03) :540-545

[8] Beneficial effects of L-carnitine in myoblastic C2Cl2 cells interaction with zidovudine [J].

Georges, B ;

Galland, S ;

Rigault, C ;

Le Borgne, F ;

Demarquoy, J .

BIOCHEMICAL PHARMACOLOGY, 2003, 65 (09) :1483-1488

[9] Palmitic acid metabolism in the soleus muscle in vitro in hypo- and hyperthyroid rats [J].

Górecka, M ;

Synak, M ;

Langfort, J ;

Kaciuba-Uscilko, H ;

Zernicka, E .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2004, 448 (04) :445-451

[10] Thyroid hormone regulates carnitine palmitoyltransferase Iα gene expression through elements in the promoter and first intron [J].

Jansen, MS ;

Cook, GA ;

Song, S ;

Park, EA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (45) :34989-34997

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