Hypoxia-inducible factors in OSCC

被引：69

作者：

Perez-Sayans, Mario ^{[1
]}

Manuel Suarez-Penaranda, Jose ^{[2
]}

Pilar, Gayoso-Diz ^{[3
]}

Barros-Angueira, Francisco ^{[4
]}

Manuel Gandara-Rey, Jose

Garcia-Garcia, Abel ^{[1
]}

机构：

[1] Inst Invest Sanitaria Santiago IDIS, Fac Med & Dent, Oral Surg & Implantol Unit, Santiago De Compostela, Spain

[2] Hosp Clin Univ Santiago, Serv Anat Patol, Santiago De Compostela 15706, Spain

[3] Hosp Clin Univ Santiago de Compostella, Clin Epidemiol & Biostat Unit, Santiago De Compostela, Spain

[4] Hosp Clin Univ Santiago de Compostella, Fdn Publ Calega Medicina Xenom, Unidad Med Mol, Santiago De Compostela, Spain

来源：

CANCER LETTERS | 2011年 / 313卷 / 01期

关键词：

Oral squamous cell carcinoma; Hypoxia-inducible factors; HIF-1; alpha; HIF-2; Hypoxia; SQUAMOUS-CELL CARCINOMA; ENDOTHELIAL GROWTH-FACTOR; CARBONIC-ANHYDRASE-IX; CANCER-THERAPY; NITRIC-OXIDE; ORAL-CANCER; NECK-CANCER; FACTOR-1-ALPHA EXPRESSION; INDUCED APOPTOSIS; FACTOR; 1-ALPHA;

D O I：

10.1016/j.canlet.2011.08.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Oral squamous cell carcinoma (OSCC) is a characteristic locally aggressive tumor in which hypoxia levels are very high, causing a low response to chemotherapy and providing basic resistance to anticancer drugs. Tumoral hypoxia directly depends on hypoxia-inducible factors (HIF). The goal of this paper is to describe HIF basic biology and tumor cells (HIF-1 alpha, mainly), analyzing the effects of its expression in OSCC, study its relation with other molecules such as nitric oxide (NO), carbonic anhydrase (CA) or VEGF and assess the possibility of its manipulation as a therapeutic target. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：1 / 8

页数：8

共 81 条

[1]

Aebersold DM, 2001, CANCER RES, V61, P2911

[2] MicroRNAs: Target Recognition and Regulatory Functions [J].

Bartel, David P. .

CELL, 2009, 136 (02) :215-233

[3]

Beasley NJP, 2002, CANCER RES, V62, P2493

[4]

Birner P, 2001, CLIN CANCER RES, V7, P1661

[5] Regulation of hypoxia-inducible factor 1 (HIF-1) by nitric oxide in oral squamous cell carcinoma [J].

Brennan, PA .

ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND, 2005, 87 (03) :153-158

[6] Hypoxia-inducible factor 1α in oral cancer [J].

Brennan, PA ;

Mackenzie, N ;

Quintero, M .

JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2005, 34 (07) :385-389

[7]

Brüne B, 2003, KIDNEY INT, V63, pS22

[8] Significant correlation of hypoxia-inducible factor-1α with treatment outcome in cervical cancer treated with radical radiotherapy [J].

Burri, P ;

Djonov, V ;

Aebersold, DM ;

Lindel, K ;

Studer, U ;

Altermatt, HJ ;

Mazzucchelli, L ;

Greiner, RH ;

Gruber, G .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2003, 56 (02) :494-501

[9]

Chang C.C., 2011, J ORAL PATHOL MED, V2011

[10] Hypoxia-inducible factor-1α is associated with risk of aggressive behavior and tumor angiogenesis in gastrointestinal stromal tumor [J].

Chen, WT ;

Huang, CJ ;

Wu, MT ;

Yang, SF ;

Su, YC ;

Chai, CY .

JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2005, 35 (04) :207-213

← 1 2 3 4 5 6 7 8 9 →