Polysomnography versus limited respiratory monitoring and nurse-led titration to optimise non-invasive ventilation set-up: a pilot randomised clinical trial

被引：23

作者：

Patout, Maxime ^{[1
,2
,3
]}

Arbane, Gill ^{[1
,3
]}

Cuvelier, Antoine ^{[2
]}

Muir, Jean Francois ^{[2
]}

Hart, Nicholas ^{[1
,3
,4
]}

Murphy, Patrick Brian ^{[1
,3
,4
]}

机构：

[1] Guys & St Thomas NHS Fdn Trust, Lane Fox Resp Unit, London, England

[2] Normandie Univ, Serv Pneumol Oncol Thorac & Soins Intensifs Resp, UNIRouen, Rouen Univ Hosp,IRIB,EA3830 GRHV, Rouen, France

[3] Guys & St Thomas NHS Fdn Trust, Lane Fox Clin Resp Physiol Res Ctr, London, England

[4] Kings Coll London, Ctr Human Aerosp & Physiol Sci, London, England

来源：

THORAX | 2019年 / 74卷 / 01期

关键词：

OBSTRUCTIVE SLEEP-APNEA; COPD;

D O I：

10.1136/thoraxjnl-2017-211067

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Polysomnography (PSG) is recommended for non-invasive ventilation (NIV) set-up in patients with chronic respiratory failure. In this pilot randomised clinical trial, we compared the physiological effectiveness of NIV set-up guided by PSG to limited respiratory monitoring (LRM) and nurse-led titration in patients with COPD-obstructive sleep apnoea (OSA) overlap. The principal outcome of interest was change in daytime arterial partial pressure of carbon dioxide (PaCO2) at 3 months. Fourteen patients with daytime PaCO2 >6 kPa and body mass index >30 kg/m(2) were recruited. At 3 months, PaCO2 was reduced by -0.88 kPa (95% CI -1.52 to -0.24 kPa) in the LRM group and by -0.36 kPa (95% CI -0.96 to 0.24 kPa) in the PSG group. These pilot data provide support to undertake a clinical trial investigating the clinical effectiveness of attended limited respiratory monitoring and PSG to establish NIV in patients with COPD-OSA overlap. Trial number .

引用

页码：83 / 86

页数：4

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