A Phase II Study of Neoadjuvant Chemotherapy Followed by Extended Field Concurrent Chemoradiotherapy for Para-aortic Lymph Node Positive Cervical Cancer

被引：11

作者：

Shimoji, Yuko ^{[1
]}

Nagai, Yutaka ^{[1
,3
,4
]}

Toita, Takafumi ^{[2
,5
]}

Ariga, Takuro ^{[2
,6
]}

Heianna, Joichi ^{[2
]}

Nakasone, Tadaharu ^{[1
]}

Taira, Yusuke ^{[1
]}

Arakaki, Yoshihisa ^{[1
]}

Nakamoto, Tomoko ^{[1
]}

Ooyama, Takuma ^{[1
]}

Kudaka, Wataru ^{[1
]}

Kaneshima, Itomi ^{[1
]}

Nishihira, Kumiko ^{[1
]}

Mekaru, Keiko ^{[1
]}

Aoki, Yoichi ^{[1
]}

机构：

[1] Univ Ryukyus, Grad Sch Med, Dept Obstet & Gynecol, 207 Uehara Nishihara, Nishihara, Okinawa 9030215, Japan

[2] Univ Ryukyus, Grad Sch Med, Dept Radiol, Nishihara, Okinawa, Japan

[3] Okinawa Prefectural Nanbu Med Ctr, Dept Obstet & Gynecol, Haebaru, Okinawa, Japan

[4] Childrens Med Ctr, Haebaru, Okinawa, Japan

[5] Okinawa Chubu Hosp, Dept Radiat Therapy Ctr, Uruma, Okinawa, Japan

[6] Univ Ryukyus Hosp, Hlth Informat Management Ctr, Nishihara, Okinawa, Japan

来源：

ANTICANCER RESEARCH | 2020年 / 40卷 / 06期

关键词：

Cervical cancer; para-aortic node metastasis; neoadjuvant chemotherapy; extended-field concurrent chemoradiotherapy; phase II study; RADIATION-THERAPY; CISPLATIN CHEMOTHERAPY; CARCINOMA; SURVIVAL; IRRADIATION; TRIAL; RADIOTHERAPY; PATTERNS; HEAD;

D O I：

10.21873/anticanres.14346

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: We conducted a phase II study of neoadjuvant chemotherapy followed by extended field concurrent chemoradiotherapy in patients with cervical cancer with para-aortic node metastasis. Patients and Methods: Thirty-seven women with stage IB1-IVA cervical cancer were enrolled. Results: The median age was 52 years. Thirty-four patients other than 3 progressive disease, proceeded to extended field concurrent chemoradiotherapy. The 3-year overall survival and progression-free survival rates were 70.1% and 48.5%, respectively. The 3-year overall survival according to stages was significantly worse in stage IIIB. Twelve of the 17 patients with stage IIIB died of the disease. Conclusion: Neoadjuvant chemotherapy followed by extended field concurrent chemoradiotherapy may improve the prognosis of patients with stages IB and II cervical cancer with positive para-aortic node. However, new strategies should be investigated to improve a poor prognosis in stage IIIB disease with positive para-aortic node.

引用

收藏

页码：3565 / 3570

页数：6

相关论文

共 27 条

[1] Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC [J].

Antonia, S. J. ;

Villegas, A. ;

Daniel, D. ;

Vicente, D. ;

Murakami, S. ;

Hui, R. ;

Kurata, T. ;

Chiappori, A. ;

Lee, K. H. ;

de Wit, M. ;

Cho, B. C. ;

Bourhaba, M. ;

Quantin, X. ;

Tokito, T. ;

Mekhail, T. ;

Planchard, D. ;

Kim, Y. -C. ;

Karapetis, C. S. ;

Hiret, S. ;

Ostoros, G. ;

Kubota, K. ;

Gray, J. E. ;

Paz-Ares, L. ;

Carpeno, J. de Castro ;

Faivre-Finn, C. ;

Reck, M. ;

Vansteenkiste, J. ;

Spigel, D. R. ;

Wadsworth, C. ;

Melillo, G. ;

Taboada, M. ;

Dennis, P. A. ;

Ozguroglu, M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 379 (24) :2342-2350

[2] Should the Presence of Metastatic Para-Aortic Lymph Nodes in Locally Advanced Cervical Cancer Lead to More Aggressive Treatment Strategies? [J].

Benito, Virginia ;

Carballo, Sonia ;

Silva, Patricia ;

Esparza, Miriam ;

Arencibia, Octavio ;

Federico, Mario ;

Andujar, Miguel ;

Mori, Marta ;

Medina, Norberto ;

Lubrano, Amina .

JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY, 2017, 24 (04) :609-616

[3] SURVIVAL AND PATTERNS OF RECURRENCE IN CERVICAL-CANCER METASTATIC TO PERIAORTIC LYMPH-NODES - (A GYNECOLOGIC ONCOLOGY GROUP-STUDY) [J].

BERMAN, ML ;

KEYS, H ;

CREASMAN, W ;

DISAIA, P ;

BUNDY, B ;

BLESSING, J .

GYNECOLOGIC ONCOLOGY, 1984, 19 (01) :8-16

[4] Phase I trial of taxol as a radiation sensitizer with cisplatin in advanced cervical cancer [J].

Chen, MD ;

Paley, PJ ;

Potish, RA ;

Twiggs, LB .

GYNECOLOGIC ONCOLOGY, 1997, 67 (02) :131-136

[5] Neoadjuvant Chemotherapy With Cisplatin and Gemcitabine Followed by Chemoradiation Versus Chemoradiation for Locally Advanced Cervical Cancer: A Randomized Phase II Trial [J].

da Costa, Samantha Cabral S. ;

Bonadio, Renata Colombo ;

Gabrielli, Flavia Carolina G. ;

Aranha, Andrea S. ;

Dias Genta, Maria Luiza N. ;

Miranda, Vanessa C. ;

de Freitas, Daniela ;

Abdo Filho, Elias ;

Ferreira, Patricia A. O. ;

Machado, Karime K. ;

Scaranti, Mariana ;

Carvalho, Heloisa de A. ;

Estevez-Diz, Maria Del Pilar .

JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (33) :3124-+

[6] Lymphadenectomy in Locally Advanced Cervical Cancer Study (LiLACS): Phase III Clinical Trial Comparing Surgical With Radio logic Staging in Patients With Stages IB2-IVA Cervical Cancer [J].

Frumovitz, Michael ;

Querleu, Denis ;

Gil-Moreno, Antonio ;

Morice, Philippe ;

Jhingran, Anuja ;

Munsell, Mark F. ;

Macapinlac, Homer A. ;

LeBlanc, Eric ;

Martinez, Alejandra ;

Ramirez, Pedro T. .

JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY, 2014, 21 (01) :3-8

[7] Long-term follow-up of RTOG 92-10: Cervical cancer with positive para-aortic lymph nodes [J].

Grigsby, PW ;

Heydon, K ;

Mutch, DG ;

Kim, RY ;

Eifel, P .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2001, 51 (04) :982-987

[8] Radiation therapy for carcinoma of the cervix with biopsy-proven positive para-aortic lymph nodes [J].

Grigsby, PW ;

Perez, CA ;

Chao, KSC ;

Herzog, T ;

Mutch, DG ;

Rader, J .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2001, 49 (03) :733-738

[9] Safety of combining radiotherapy with immune-checkpoint inhibition [J].

Hwang, William L. ;

Pike, Luke R. G. ;

Royce, Trevor J. ;

Mahal, Brandon A. ;

Loeffler, Jay S. .

NATURE REVIEWS CLINICAL ONCOLOGY, 2018, 15 (08) :477-494

[10] 5-YEAR SURVIVAL OF PATIENTS WITH PERIAORTIC NODAL METASTASES IN CLINICAL STAGE-IB AND STAGE-IIA CERVICAL-CARCINOMA [J].

LOVECCHIO, JL ;

AVERETTE, HE ;

DONATO, D ;

BELL, J .

GYNECOLOGIC ONCOLOGY, 1989, 34 (01) :43-45