A Phase II Study of Neoadjuvant Chemotherapy Followed by Extended Field Concurrent Chemoradiotherapy for Para-aortic Lymph Node Positive Cervical Cancer

被引：10

作者：

Shimoji, Yuko ^{[1
]}

Nagai, Yutaka ^{[1
,3
,4
]}

Toita, Takafumi ^{[2
,5
]}

Ariga, Takuro ^{[2
,6
]}

Heianna, Joichi ^{[2
]}

Nakasone, Tadaharu ^{[1
]}

Taira, Yusuke ^{[1
]}

Arakaki, Yoshihisa ^{[1
]}

Nakamoto, Tomoko ^{[1
]}

Ooyama, Takuma ^{[1
]}

Kudaka, Wataru ^{[1
]}

Kaneshima, Itomi ^{[1
]}

Nishihira, Kumiko ^{[1
]}

Mekaru, Keiko ^{[1
]}

Aoki, Yoichi ^{[1
]}

机构：

[1] Univ Ryukyus, Grad Sch Med, Dept Obstet & Gynecol, 207 Uehara Nishihara, Nishihara, Okinawa 9030215, Japan

[2] Univ Ryukyus, Grad Sch Med, Dept Radiol, Nishihara, Okinawa, Japan

[3] Okinawa Prefectural Nanbu Med Ctr, Dept Obstet & Gynecol, Haebaru, Okinawa, Japan

[4] Childrens Med Ctr, Haebaru, Okinawa, Japan

[5] Okinawa Chubu Hosp, Dept Radiat Therapy Ctr, Uruma, Okinawa, Japan

[6] Univ Ryukyus Hosp, Hlth Informat Management Ctr, Nishihara, Okinawa, Japan

来源：

ANTICANCER RESEARCH | 2020年 / 40卷 / 06期

关键词：

Cervical cancer; para-aortic node metastasis; neoadjuvant chemotherapy; extended-field concurrent chemoradiotherapy; phase II study; RADIATION-THERAPY; CISPLATIN CHEMOTHERAPY; CARCINOMA; SURVIVAL; IRRADIATION; TRIAL; RADIOTHERAPY; PATTERNS; HEAD;

D O I：

10.21873/anticanres.14346

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: We conducted a phase II study of neoadjuvant chemotherapy followed by extended field concurrent chemoradiotherapy in patients with cervical cancer with para-aortic node metastasis. Patients and Methods: Thirty-seven women with stage IB1-IVA cervical cancer were enrolled. Results: The median age was 52 years. Thirty-four patients other than 3 progressive disease, proceeded to extended field concurrent chemoradiotherapy. The 3-year overall survival and progression-free survival rates were 70.1% and 48.5%, respectively. The 3-year overall survival according to stages was significantly worse in stage IIIB. Twelve of the 17 patients with stage IIIB died of the disease. Conclusion: Neoadjuvant chemotherapy followed by extended field concurrent chemoradiotherapy may improve the prognosis of patients with stages IB and II cervical cancer with positive para-aortic node. However, new strategies should be investigated to improve a poor prognosis in stage IIIB disease with positive para-aortic node.

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页码：3565 / 3570

页数：6

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