Combining proteomics and genetic screens to identify KRAS synthetic lethal interactions.

被引:0
|
作者
Sheth, S. [1 ,2 ]
Cook, Danielle R. [1 ,2 ]
Strasser, Samantha D. [3 ]
Martin, Timothy D. [4 ]
Menon, Sneha [1 ,2 ]
Popow, Olesja [1 ,2 ]
Paulo, Joao A. [1 ,2 ]
Elledge, Steve J. [4 ]
Haigis, Kevin M. [1 ,2 ]
机构
[1] Harvard Med Sch, Canc Res Inst, Beth Israel Deaconess Canc Ctr, Boston, MA 02115 USA
[2] Harvard Med Sch, Dept Med, Boston, MA 02115 USA
[3] MIT, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA
[4] Harvard Univ, Sch Med, Program Virol, Boston, MA USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
B09
引用
收藏
页码:58 / 58
页数:1
相关论文
共 50 条
  • [21] Chemical genetic screening of KRAS-based synthetic lethal inhibitors for pancreatic cancer
    Ji, Zhenyu
    Mei, Fang C.
    Lory, Pedro L.
    Gilbertson, Scott R.
    Chen, Yijun
    Cheng, Xiaodong
    FRONTIERS IN BIOSCIENCE-LANDMARK, 2009, 14 : 2904 - 2910
  • [22] A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
    Marhold, Maximilian
    Heinzel, Andreas
    Merchant, Almas
    Perco, Paul
    Krainer, Michael
    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2021, (171):
  • [23] Synthetic lethal interactions identify phenotypic "interologs" of the spindle assembly checkpoint components
    Tarailo, Maja
    Tarailo, Sanja
    Rose, Ann M.
    GENETICS, 2007, 177 (04) : 2525 - 2530
  • [25] Synthetic Lethal Screens Identify Vulnerabilities in GPCR Signaling and Cytoskeletal Organization in E-Cadherin-Deficient Cells
    Telford, Bryony J.
    Chen, Augustine
    Beetham, Henry
    Frick, James
    Brew, Tom P.
    Gould, Cathryn M.
    Single, Andrew
    Godwin, Tanis
    Simpson, Kaylene J.
    Guilford, Parry
    MOLECULAR CANCER THERAPEUTICS, 2015, 14 (05) : 1213 - 1223
  • [26] Genetic interactions with Saccharomyces cerevisiae TFIIS:: Results of a synthetic lethal screen
    Davie, JK
    Kane, CM
    FASEB JOURNAL, 1997, 11 (09): : A1372 - A1372
  • [27] ASTER: A Method to Predict Clinically Relevant Synthetic Lethal Genetic Interactions
    Liany, Herty
    Jayagopal, Aishwarya
    Huang, Dachuan
    Lim, Jing Quan
    Nbh, Nur Izzah
    Jeyasekharan, Anand
    Ong, Choon Kiat
    Rajan, Vaibhav
    IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS, 2024, 28 (03) : 1785 - 1796
  • [28] Predicting yeast synthetic lethal genetic interactions using protein domains
    Li, Bo
    Luo, Feng
    2009 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE, 2009, : 43 - 47
  • [29] GEMINI: a variational Bayesian approach to identify genetic interactions from combinatorial CRISPR screens
    Mahdi Zamanighomi
    Sidharth S. Jain
    Takahiro Ito
    Debjani Pal
    Timothy P. Daley
    William R. Sellers
    Genome Biology, 20
  • [30] GEMINI: a variational Bayesian approach to identify genetic interactions from combinatorial CRISPR screens
    Zamanighomi, Mahdi
    Jain, Sidharth S.
    Ito, Takahiro
    Pal, Debjani
    Daley, Timothy P.
    Sellers, William R.
    GENOME BIOLOGY, 2019, 20 (1)