Paeonol Derivatives and Pharmacological Activities: A Review of Recent Progress

被引：44

作者：

Wang, Jilei ^{[1
,2
]}

Wu, Guiying ^{[1
,2
]}

Chu, Haiping ^{[2
,3
,4
]}

Wu, Zhongyu ^{[2
,3
,4
]}

Sun, Jingyong ^{[2
,3
,4
]}

机构：

[1] Univ Jinan, Sch Med & Life Sci, Shandong Acad Med Sci, Jinan, Peoples R China

[2] Shandong Acad Med Sci, Inst Mat Med, Jinan, Peoples R China

[3] Minist Hlth, Kev Lab Biotech Drugs, Jinan, Peoples R China

[4] Key Lab Rare & Uncommon Dis Shandong Prov, Jinan, Peoples R China

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2020年 / 20卷 / 06期

关键词：

Paeonol derivatives; pharmacological activities; anti-inflammatory; antitumor; antibacterial; cardiovascular; antioxidant; anti-enzyme; ACUTE LUNG INJURY; IN-VITRO; COPPER(II) COMPLEXES; ANTIPROLIFERATIVE ACTIVITY; BIOLOGICAL EVALUATION; ENDOTHELIAL-CELLS; KAPPA-B; DESIGN; POTENT; INHIBITORS;

D O I：

10.2174/1389557519666191015204223

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Paeonol, 2-hydroxy-4-methoxy acetophenone, is one of the main active ingredients of traditional Chinese medicine such as Cynanchum paniculaium, Paeonia suffrulicosa Anch. and Paeonia lc/co:flora Pall. Modern medical research has shown that paeonol has a wide range of pharmacological activities. In recent years, a large number of studies have been carried out on the structure modification of paeonol and the mechanism of action of paeonol derivatives has been studied. Some paeonol derivatives exhibit good pharmacological activities in terms of antibacterial, anti-inflammatory, antipyretic analgesic, antioxidant and other pharmacological effects. Herein, the research progress on paeonol derivatives and their pharmacological activities were systematically reviewed.

引用

页码：466 / 482

页数：17

共 114 条

[1] Design, synthesis and in vitro antitumor activity of 4-aminoquinoline and 4-aminoquinazoline derivatives targeting EGFR tyrosine kinase [J].