Mitochondrial dysfunction and genetic heterogeneity in chronic periodontitis

被引：54

作者：

Govindaraj, Periyasamy ^{[1
]}

Khan, Nahid Akhtar ^{[1
]}

Gopalakrishna, Praturi ^{[1
]}

Chandra, Rampalli Viswa ^{[2
]}

Vanniarajan, Ayyasamy ^{[1
]}

Reddy, Aileni Amarendra ^{[2
]}

Singh, Shashi ^{[1
]}

Kumaresan, Rathinam ^{[1
]}

Srinivas, Gunda ^{[1
]}

Singh, Lalji ^{[1
,3
]}

Thangaraj, Kumarasamy ^{[1
]}

机构：

[1] CSIR, Ctr Cellular & Mol Biol, Hyderabad 500007, Andhra Pradesh, India

[2] SVS Inst Dent Sci, Mahabubnagar, Andhra Pradesh, India

[3] Genome Fdn, Hyderabad, Andhra Pradesh, India

来源：

MITOCHONDRION | 2011年 / 11卷 / 03期

关键词：

Chronic periodontitis; Mitochondria; mtDNA; Mutations; ROS; NEUTROPHIL-MEDIATED DAMAGE; OXIDATIVE DNA-DAMAGE; MUTATION; IDENTIFICATION; SEQUENCE; ORIGIN; TISSUE;

D O I：

10.1016/j.mito.2011.01.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We performed an extensive study on mitochondrial dysfunction in chronic periodontitis (CP). Electron microscopic analysis of gingival cells revealed abnormal mitochondria in 60% of the patients. Mitochondrial membrane potential and oxygen consumption of gingival cells were reduced by 4 fold and 5.8 fold, respectively; whereas ROS production was increased by 18%. The genetic analysis by complete mitochondrial DNA sequencing revealed the identification of 14 novel mutations only in periodontal tissues but not in the blood, suggesting a role of oxidative stress on periodontal tissues. Thus, our functional and genetic analysis provided an evidence for the mitochondrial dysfunction in CP. (C) 2011 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

引用

页码：504 / 512

页数：9

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