Baseline Patient-Reported Outcomes Correlate Weakly With Radiographic Parameters A Multicenter, Prospective NIH Adult Symptomatic Lumbar Scoliosis Study of 286 Patients

被引：30

作者：

Chapman, Todd M., Jr. ^{[1
]}

Baldus, Christine R. ^{[1
]}

Lurie, Jon D.

Glassman, Steven D. ^{[2
]}

Schwab, Frank J. ^{[3
]}

Shaffrey, Christopher I. ^{[4
]}

Lafage, Virginie ^{[3
]}

Boachie-Adjei, Oheneba ^{[3
]}

Kim, Han J. ^{[3
]}

Smith, Justin S. ^{[4
]}

Crawford, Charles H., III ^{[2
]}

Lenke, Lawrence G. ^{[5
]}

Buchowski, Jacob M. ^{[1
]}

Edwards, Charles, II ^{[6
]}

Koski, Tyler ^{[7
]}

Parent, Stefan ^{[8
]}

Lewis, Stephen ^{[9
]}

Kang, Daniel G. ^{[1
]}

McClendon, Jamal, Jr. ^{[1
]}

Metz, Lionel ^{[1
]}

Zebala, Lukas P. ^{[1
]}

Kelly, Michael P. ^{[1
]}

Spratt, Kevin F.

Bridwell, Keith H. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, St Louis, MO USA

[2] Univ Louisville, Louisville, KY 40292 USA

[3] Hosp Special Surg, 535 E 70th St, New York, NY 10021 USA

[4] Univ Virginia, Charlottesville, VA USA

[5] Columbia Univ, New York, NY USA

[6] Mercy Med Ctr, Baltimore, MD USA

[7] Northwestern Univ, Evanston, IL USA

[8] St Justine Univ Hosp, Montreal, PQ, Canada

[9] Toronto Western Hosp, UHN Orthoped, Toronto, ON, Canada

来源：

SPINE | 2016年 / 41卷 / 22期

关键词：

adult symptomatic lumbar scoliosis; patient-reported outcomes; sagittal and coronal radiographic parameter; ADULT SPINAL DEFORMITY; SCOLIOSIS;

D O I：

10.1097/BRS.0000000000001613

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Study Design. Prospective, cross-sectional study. Objective. The aim of the study was to determine which radiographic parameters drive patient-reported outcomes (PROs) in primary presentation adult symptomatic lumbar scoliosis (ASLS). Summary of Background Data. Previous literature suggests correlations between PROs and sagittal plane deformity (sagittal vertical axis [SVA], pelvic incidence-lumbar lordosis [PI-LL] mismatch, pelvic tilt [PT]). Prior work included revision and primary adult spinal deformity patients. The present study addresses only primary presentation ASLS. Methods. Prospective baseline data were analyzed on 286 patients enrolled in an NIH RO1 clinical trial by nine centers from 2010 to 2014. Inclusion criteria: 40 to 80 years old, lumbar Cobb (LC) 308 or higher and Scoliosis Research Society-23 score 4.0 or less in Pain, Function or Self-Image domains, or Oswestry Disability Index (ODI) 20 or higher. Patients were primary presentation (no prior spinal deformity surgery) and had complete baseline data: standing coronal/sagittal 36 '' radiographs and PROs (ODI, Scoliosis Research Society-23, Short Form-12). Correlation coefficients were calculated to evaluate relations between radiographic parameters and PROs for the study population and a subset of patients with ODI 40 or higher. Analysis of variance was used to identify differences in PROs for radiographic modifier groups. Results. Mean age was 60.3 years. Mean spinopelvic parameters were: LL = -39.2 degrees; SVA = 3.1 cm; sacral slope = 32.5 degrees; PT = 23.9 degrees; PI-LL mismatch = 16.8 degrees. Only weak correlations (0.2-0.4) were identified between population sacral slope, SVA and SVA modifiers, and SRS function. SVA and SVA modifiers were weakly associated with ODI. Although there were more correlations in subset analysis of high-symptom patients, all were weak. Analysis of variance identified significant differences in ODI reported by SVA modifier groups. Conclusion. In primary presentation patients with ASLS and a subset of "high-symptom'' patients (ODI >= 40), only weak associations between baseline PROs and radiographic parameters were identified. For this patient population, these results suggest regional radiographic parameters (LC, LL, PT, PILL mismatch) are not drivers of PROs and cannot be used to extrapolate effect on patient-perceived pathology.

引用

页码：1701 / 1708

页数：8

共 11 条

[1] The impact of positive sagittal balance in adult spinal deformity [J].