Congeners of SMAP29 kill ovine pathogens and induce ultrastructural damage in bacterial cells

被引：75

作者：

Kalfa, VC

Jia, HP

Kunkle, RA

McCray, PB

Tack, BF

Brogden, KA

机构：

[1] USDA ARS, Natl Anim Dis Ctr, Resp Dis Livestock Res Unit, Ames, IA 50010 USA

[2] Univ Iowa, Coll Med, Dept Pediat, Iowa City, IA 52242 USA

[3] Univ Iowa, Coll Med, Dept Microbiol, Iowa City, IA 52242 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 11期

关键词：

D O I：

10.1128/AAC.45.11.3256-3261.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

SMAP29, an ovine cathelicidin, was systematically altered to create a family of 23 related peptides for MIC and minimum bactericidal concentration determinations. SMAP28, SMAP29, and a derivative of SMAP29 called ovispirin were all antimicrobial. However, many congeners of SMAP29 and ovispirin were not as active as the parent molecules. With immunoelectron microscopy, SMAP29 was seen on membranes and within the cytoplasm of Pseudomonas aeruginosa PAO1.

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页码：3256 / 3261

页数：6

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