Yeast Model of Amyloid-β and Tau Aggregation in Alzheimer's Disease

被引：14

作者：

Moosavi, Behrooz ^{[1
]}

Mousavi, Bibimaryam ^{[2
]}

Macreadie, Ian G. ^{[3
]}

机构：

[1] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan, Peoples R China

[2] Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Lab Organometall Catalysis & Ordered Mat, Wuhan 430070, Peoples R China

[3] RMIT Univ, Sch Appl Sci, Bundoora, Vic, Australia

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2015年 / 47卷 / 01期

关键词：

Alzheimer's disease; amyloid; protein aggregation; tau protein; yeasts; NEURONAL CELL-CYCLE; HUMAN PROTEIN-TAU; A-BETA; PRECURSOR PROTEIN; MICROTUBULE-BINDING; COGNITIVE DEFICITS; MOLECULAR-BASIS; OLIGOMERS; PEPTIDE; MEMORY;

D O I：

10.3233/JAD-150173

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The amyloid-beta peptide (A beta) and the phosphorylated protein tau have been widely implicated in Alzheimer's disease and are the focus of most research. Both agents have been extensively studied in mammalian cell culture and in animal studies, but new research is focusing on yeast models. Yeast are eukaryotes, just like us, and are amenable to effects and expression of A beta and tau and appear able to 'report' with considerable relevance on the effects of these biomolecules. The use of yeast enables powerful new approaches to understanding how to overcome the effects of A beta and tau, and such advances could lead to new therapies to prevent the progression of Alzheimer's disease.

引用

页码：9 / 16

页数：8

共 80 条

[1] Modulation of Aβ42 low-n oligomerization using a novel yeast reporter system [J].

Bagriantsev, Sviatoslav ;

Liebman, Susan .

BMC BIOLOGY, 2006, 4 (1)

[2] Accumulation of pathological tau species and memory loss in a conditional model of tauopathy [J].

Berger, Zdenek ;

Roder, Hanno ;

Hanna, Amanda ;

Carlson, Aaron ;

Rangachari, Vijayaraghavan ;

Yue, Mei ;

Wszolek, Zbigniew ;

Ashe, Karen ;

Knight, Joshua ;

Dickson, Dennis ;

Andorfer, Cathy ;

Rosenberry, Terrone L. ;

Lewis, Jada ;

Hutton, Mike ;

Janus, Christopher .

JOURNAL OF NEUROSCIENCE, 2007, 27 (14) :3650-3662

[3] Natural polyphenols as inhibitors of amyloid aggregation. Molecular dynamics study of GNNQQNY heptapeptide decamer [J].

Berhanu, Workalemahu M. ;

Masunov, Artem E. .

BIOPHYSICAL CHEMISTRY, 2010, 149 (1-2) :12-21

[4]

Bharadwaj P, 2008, J ALZHEIMERS DIS, V13, P147

[5] Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid [J].

Braak, Heiko ;

Zetterberg, Henrik ;

Del Tredici, Kelly ;

Blennow, Kaj .

ACTA NEUROPATHOLOGICA, 2013, 126 (05) :631-641

[6]

Bretteville A, 2008, J ALZHEIMERS DIS, V14, P431

[7] Alzheimer's Aβ fused to green fluorescent protein induces growth stress and a heat shock response [J].

Caine, Jo ;

Sankovich, Sonia ;

Antony, Helma ;

Waddington, Lynne ;

Macreadie, Peter ;

Varghese, Jose ;

Macreadie, Ian .

FEMS YEAST RESEARCH, 2007, 7 (08) :1230-1236

[8]

Chacinska A, 2002, LETT PEPT SCI, V9, P197, DOI 10.1023/A:1024162427326

[9] Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease [J].

Chesser, Adrianne S. ;

Pritchard, Susanne M. ;

Johnson, Gail V. W. .

FRONTIERS IN NEUROLOGY, 2013, 4

[10] The neuronal cell cycle as a mechanism of pathogenesis in Alzheimer's disease [J].

Currais, Antonio ;

Hortobagyi, Tibor ;

Soriano, Salvador .

AGING-US, 2009, 1 (04) :363-371

← 1 2 3 4 5 6 7 8 →