Public health measures to control the spread of antimicrobial resistance in Neisseria gonorrhoeae in men who have sex with men

被引:21
|
作者
Xiridou, M. [1 ]
Soetens, L. C. [1 ]
Koedijk, F. D. H. [1 ,2 ]
Van Der Sande, M. A. B. [1 ,3 ]
Wallinga, J. [1 ]
机构
[1] Natl Inst Publ Hlth & Environm, Ctr Infect Dis Control, NL-3720 BA Bilthoven, Netherlands
[2] Municipal Hlth Serv Twente, Enschede, Netherlands
[3] Univ Med Ctr, Julius Ctr, Utrecht, Netherlands
来源
EPIDEMIOLOGY AND INFECTION | 2015年 / 143卷 / 08期
关键词
Antibiotics; antimicrobial agents; antimicrobial resistance; gonorrhoea; gonorrhoea prevention and control; mathematical model; men who have sex with men; ANTIBIOTIC-RESISTANCE; TRANSMISSION DYNAMICS; STAPHYLOCOCCUS-AUREUS; EPIDEMIOLOGY; CEFTRIAXONE; NETHERLANDS; EVOLUTION; IMPACT; DRUG; INFECTION;
D O I
10.1017/S0950268814002519
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Gonorrhoea is one of the most common sexually transmitted infections. The control of gonorrhoea is extremely challenging because of the repeated development of resistance to the antibiotics used for its treatment. We explored different strategies to control the spread of antimicrobial resistance and prevent increases in gonorrhoea prevalence. We used a mathematical model that describes gonorrhoea transmission among men who have sex with men and distinguishes gonorrhoea strains sensitive or resistant to three antibiotics. We investigated the impact of combination therapy, switching first-line antibiotics according to resistance thresholds, and other control efforts (reduced sexual risk behaviour, increased treatment rate). Combination therapy can delay the spread of resistance better than using the 5% resistance threshold. Increased treatment rates, expected to enhance gonorrhoea control, may reduce gonorrhoea prevalence only in the short term, but could lead to more resistance and higher prevalence in the long term. Re-treatment of resistant cases with alternative antibiotics can substantially delay the spread of resistance. In conclusion, combination therapy and re-treatment of resistant cases with alternative antibiotics could be the most effective strategies to prevent increases in gonorrhoea prevalence due to antimicrobial resistance.
引用
收藏
页码:1575 / 1584
页数:10
相关论文
共 50 条
  • [31] Re-infection of Neisseria gonorrhoeae and Chlamydia trachomatis infections among men who have sex with men
    Lister, N. A.
    Smith, A.
    Tabrizi, S. N.
    Garland, S.
    Fairley, C. K.
    INTERNATIONAL JOURNAL OF STD & AIDS, 2006, 17 (06) : 415 - 417
  • [32] Determining the Most Likely Source of Infection An Application to Neisseria Gonorrhoeae Among Men Who Have Sex with Men
    Matser, Amy
    van der Loeff, Maarten Schim
    Geskus, Ronald
    EPIDEMIOLOGY, 2018, 29 (03) : 421 - 430
  • [33] ARE WE SEEING A TRUE RISE IN NEISSERIA GONORRHOEAE AND CHLAMYDIA TRACHOMATIS IN ENGLAND IN MEN WHO HAVE SEX WITH MEN?
    Haidari, G.
    Perry, M. E. O.
    White, J. A.
    SEXUALLY TRANSMITTED INFECTIONS, 2013, 89 : A185 - A185
  • [34] Screening for Neisseria gonorrhoeae and Chlamydia trachomatis in men who have sex with men at male-only saunas
    Lister, NA
    Smith, A
    Tabrizi, S
    Hayes, P
    Medland, NA
    Garland, S
    Fairley, CK
    SEXUALLY TRANSMITTED DISEASES, 2003, 30 (12) : 886 - 889
  • [35] Differing Neisseria gonorrhoeae Bacterial Loads in the Pharynx and Rectum in Men Who Have Sex with Men: Implications for Gonococcal Detection, Transmission, and Control
    Bissessor, M.
    Tabrizi, S. N.
    Fairley, C. K.
    Danielewski, J.
    Whitton, B.
    Bird, S.
    Garland, S.
    Chen, M. Y.
    JOURNAL OF CLINICAL MICROBIOLOGY, 2011, 49 (12) : 4304 - 4306
  • [36] CO-INFECTION AND MACROLIDE ANTIMICROBIAL RESISTANCE (AMR) OF MYCOPLASMA GENITALIUM WITH NEISSERIA GONORRHOEAE AND CHLAMYDIA TRACHOMATIS, IN FEMALES, HETEROSEXUAL MALES, AND MEN-WHO-HAVE-SEX-WITH-MEN
    Broad, Claire Elizabeth
    Harding-Esch, Emma
    Harrison, Mark
    Pond, Marcus James
    Tan, Ngeekeong
    Okala, Sandra
    Soares, Clare
    Fuller, Sebastian
    Sadiq, Syed Tariq
    SEXUALLY TRANSMITTED INFECTIONS, 2017, 93 : A27 - A27
  • [37] Comparing men who have sex with women, men who have sex with men only and men who have sex with men and women visiting a public STD clinic
    Reese, Amanda C.
    Ghanem, Khalil G.
    Gilliams, Elizabeth
    Hamill, Matthew M.
    Tuddenham, Susan
    SEXUALLY TRANSMITTED DISEASES, 2024, 51 (01) : S248 - S249
  • [38] Prevalence of pharyngeal and rectal Chlamydia trachomatis and Neisseria gonorrhoeae infections among men who have sex with men in Germany
    Dudareva-Vizule, Sandra
    Haar, Karin
    Sailer, Andrea
    Wisplinghoff, Hilmar
    Wisplinghoff, Fabian
    Marcus, Ulrich
    SEXUALLY TRANSMITTED INFECTIONS, 2014, 90 (01) : 46 - 51
  • [39] Rate of repeat diagnoses in men who have sex with men for Chlamydia trachomatis and Neisseria gonorrhoeae: a retrospective cohort study
    Marinelli, Tess
    Chow, Eric P. F.
    Tomnay, Jane
    Fehler, Glenda
    Bradshaw, Catriona S.
    Chen, Marcus Y.
    Forcey, Dana S.
    Fairley, Christopher K.
    SEXUAL HEALTH, 2015, 12 (05) : 418 - 424
  • [40] Screening of asymptomatic Chlamydia trachomatis and Neisseria gonorrhoeae infections among men who have sex with men in Hong Kong
    Chau, C. T.
    Ho, K. M.
    Ho, C. K.
    HONG KONG JOURNAL OF DERMATOLOGY & VENEREOLOGY, 2016, 24 (03): : 113 - 119