[2] Municipal Hlth Serv Twente, Enschede, Netherlands
[3] Univ Med Ctr, Julius Ctr, Utrecht, Netherlands
来源:
EPIDEMIOLOGY AND INFECTION
|
2015年
/
143卷
/
08期
关键词:
Antibiotics;
antimicrobial agents;
antimicrobial resistance;
gonorrhoea;
gonorrhoea prevention and control;
mathematical model;
men who have sex with men;
ANTIBIOTIC-RESISTANCE;
TRANSMISSION DYNAMICS;
STAPHYLOCOCCUS-AUREUS;
EPIDEMIOLOGY;
CEFTRIAXONE;
NETHERLANDS;
EVOLUTION;
IMPACT;
DRUG;
INFECTION;
D O I:
10.1017/S0950268814002519
中图分类号:
R1 [预防医学、卫生学];
学科分类号:
1004 ;
120402 ;
摘要:
Gonorrhoea is one of the most common sexually transmitted infections. The control of gonorrhoea is extremely challenging because of the repeated development of resistance to the antibiotics used for its treatment. We explored different strategies to control the spread of antimicrobial resistance and prevent increases in gonorrhoea prevalence. We used a mathematical model that describes gonorrhoea transmission among men who have sex with men and distinguishes gonorrhoea strains sensitive or resistant to three antibiotics. We investigated the impact of combination therapy, switching first-line antibiotics according to resistance thresholds, and other control efforts (reduced sexual risk behaviour, increased treatment rate). Combination therapy can delay the spread of resistance better than using the 5% resistance threshold. Increased treatment rates, expected to enhance gonorrhoea control, may reduce gonorrhoea prevalence only in the short term, but could lead to more resistance and higher prevalence in the long term. Re-treatment of resistant cases with alternative antibiotics can substantially delay the spread of resistance. In conclusion, combination therapy and re-treatment of resistant cases with alternative antibiotics could be the most effective strategies to prevent increases in gonorrhoea prevalence due to antimicrobial resistance.
机构:
Robert Koch Inst, Dept Infect Dis Epidemiol, HIV AIDS STI & Bloodborne Infect Unit, D-13086 Berlin, GermanyRobert Koch Inst, Dept Infect Dis Epidemiol, HIV AIDS STI & Bloodborne Infect Unit, D-13086 Berlin, Germany
Haar, Karin
Sailer, Andrea
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机构:
Robert Koch Inst, Dept Infect Dis Epidemiol, HIV AIDS STI & Bloodborne Infect Unit, D-13086 Berlin, GermanyRobert Koch Inst, Dept Infect Dis Epidemiol, HIV AIDS STI & Bloodborne Infect Unit, D-13086 Berlin, Germany
Sailer, Andrea
Wisplinghoff, Hilmar
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机构:
Labs Med Koln Drs Wisplinghoff & Colleagues, Cologne, GermanyRobert Koch Inst, Dept Infect Dis Epidemiol, HIV AIDS STI & Bloodborne Infect Unit, D-13086 Berlin, Germany
Wisplinghoff, Hilmar
Wisplinghoff, Fabian
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机构:
Labs Med Koln Drs Wisplinghoff & Colleagues, Cologne, GermanyRobert Koch Inst, Dept Infect Dis Epidemiol, HIV AIDS STI & Bloodborne Infect Unit, D-13086 Berlin, Germany
机构:
Alfred Hlth, Melbourne Sexual Hlth Ctr, Carlton, Vic 3053, AustraliaAlfred Hlth, Melbourne Sexual Hlth Ctr, Carlton, Vic 3053, Australia
Marinelli, Tess
Chow, Eric P. F.
论文数: 0引用数: 0
h-index: 0
机构:
Alfred Hlth, Melbourne Sexual Hlth Ctr, Carlton, Vic 3053, Australia
Monash Univ, Fac Med Nursing & Hlth Sci, Cent Clin Sch, Melbourne, Vic 3004, AustraliaAlfred Hlth, Melbourne Sexual Hlth Ctr, Carlton, Vic 3053, Australia
Chow, Eric P. F.
Tomnay, Jane
论文数: 0引用数: 0
h-index: 0
机构:
Univ Melbourne, Melbourne Med Sch, Ctr Excellence Rural Sexual Hlth, Shepparton, Vic 3630, AustraliaAlfred Hlth, Melbourne Sexual Hlth Ctr, Carlton, Vic 3053, Australia
Tomnay, Jane
Fehler, Glenda
论文数: 0引用数: 0
h-index: 0
机构:
Alfred Hlth, Melbourne Sexual Hlth Ctr, Carlton, Vic 3053, AustraliaAlfred Hlth, Melbourne Sexual Hlth Ctr, Carlton, Vic 3053, Australia
Fehler, Glenda
Bradshaw, Catriona S.
论文数: 0引用数: 0
h-index: 0
机构:
Alfred Hlth, Melbourne Sexual Hlth Ctr, Carlton, Vic 3053, Australia
Monash Univ, Fac Med Nursing & Hlth Sci, Cent Clin Sch, Melbourne, Vic 3004, AustraliaAlfred Hlth, Melbourne Sexual Hlth Ctr, Carlton, Vic 3053, Australia
Bradshaw, Catriona S.
Chen, Marcus Y.
论文数: 0引用数: 0
h-index: 0
机构:
Alfred Hlth, Melbourne Sexual Hlth Ctr, Carlton, Vic 3053, Australia
Monash Univ, Fac Med Nursing & Hlth Sci, Cent Clin Sch, Melbourne, Vic 3004, AustraliaAlfred Hlth, Melbourne Sexual Hlth Ctr, Carlton, Vic 3053, Australia
Chen, Marcus Y.
Forcey, Dana S.
论文数: 0引用数: 0
h-index: 0
机构:
Alfred Hlth, Melbourne Sexual Hlth Ctr, Carlton, Vic 3053, AustraliaAlfred Hlth, Melbourne Sexual Hlth Ctr, Carlton, Vic 3053, Australia
Forcey, Dana S.
Fairley, Christopher K.
论文数: 0引用数: 0
h-index: 0
机构:
Alfred Hlth, Melbourne Sexual Hlth Ctr, Carlton, Vic 3053, Australia
Monash Univ, Fac Med Nursing & Hlth Sci, Cent Clin Sch, Melbourne, Vic 3004, AustraliaAlfred Hlth, Melbourne Sexual Hlth Ctr, Carlton, Vic 3053, Australia