No association found between the promoter variants of TNF-α and diabetic retinopathy in chinese patients with type 2 diabetes

被引：12
|
作者：
Wang, N. [1 ]
Huang, K. [2 ,3 ]
Zou, H. [1 ]
Shi, Y. [2 ,3 ]
Zhu, J. [4 ]
Tang, W. [2 ,3 ]
Xu, X. [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Affiliated First Peoples Hosp, Dept Ophthalmol, Shanghai 200080, Peoples R China
[2] Shanghai Jiao Tong Univ, Biox Ctr, Shanghai 200030, Peoples R China
[3] Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai, Peoples R China
[4] Shanghai Municipal Ctr Eye Dis Prevent & Treatmen, Shanghai, Peoples R China
来源：
CURRENT EYE RESEARCH | 2008年 / 33卷 / 04期
基金：
中国国家自然科学基金;
关键词：
association; case-control; diabetic retinopathy; promoter; TNF-alpha;
D O I：
10.1080/02713680802008220
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Purpose: Necrosis tumor factor (TNF) is known to be associated with diabetic retinopathy (DR). The objective of this study was to examine the genetic variations of TNF-alpha and assess their possible relationship to DR in type 2 diabetic patients in the Chinese population. Materials and Methods: We conducted a case-control association study between the promoter variants of TNF-alpha and diabetic retinopathy in Chinese patients with type 2 diabetes. We selected three variants in the promoter region of TNF-alpha, namely rs1800629, rs1041981, and rs2857713. Results: No individual SNP nor any haplotype was found to be associated with DR in our study. Conclusion: This is the first study to report TNF-alpha polymorphisms in patients with DR in the Chinese population. The results suggest that the variants among the promoter of TNF-alpha are unlikely to play a major role in the susceptibility to DR in Chinese patients with type 2 diabetes.
引用
收藏
页码：377 / 383
页数：7
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