The role of complement in ocular pathology

被引：59

作者：

Bora, Nalini S. ^{[1
]}

Jha, Purushottam ^{[1
]}

Bora, Puran S. ^{[1
]}

机构：

[1] Univ Arkansas Med Sci, Dept Ophthalmol, Jones Eye Inst, Little Rock, AR 72205 USA

来源：

SEMINARS IN IMMUNOPATHOLOGY | 2008年 / 30卷 / 02期

关键词：

complement system; complement regulatory proteins; eye; corneal inflammation; uveitis; age-related macular degeneration;

D O I：

10.1007/s00281-008-0110-y

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Functionally active complement system and complement regulatory proteins are present in the normal human and rodent eye. Complement activation and its regulation by ocular complement regulatory proteins contribute to the pathology of various ocular diseases including keratitis, uveitis and age-related macular degeneration. Furthermore, a strong relationship between age-related macular degeneration and polymorphism in the genes of certain complement components/complement regulatory proteins is now well established. Recombinant forms of the naturally occurring complement regulatory proteins have been exploited in the animal models for treatment of these ocular diseases. It is hoped that in the future recombinant complement regulatory proteins will be used as novel therapeutic agents in the clinic for the treatment of keratitis, uveitis, and age-related macular degeneration.

引用

页码：85 / 95

页数：11

共 99 条

[81]

Prendergast RA, 1998, INVEST OPHTH VIS SCI, V39, P754

[82] Structural basis for complement factor H-linked age-related macular degeneration [J].

Prosser, Beverly E. ;

Johnson, Steven ;

Roversi, Pietro ;

Herbert, Andrew P. ;

Blaum, Barbel S. ;

Tyrrell, Jess ;

Jowitt, Thomas A. ;

Clark, Simon J. ;

Tarelli, Edward ;

Uhrin, Dusan ;

Barlow, Paul N. ;

Sim, Robert B. ;

Day, Anthony J. ;

Lea, Susan M. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (10) :2277-2283

[83] Identification and functional characterization of a new gene encoding the mouse terminal complement inhibitor CD59 [J].

Qian, YM ;

Qin, XB ;

Miwa, T ;

Sun, XJ ;

Halperin, JA ;

Song, WC .

JOURNAL OF IMMUNOLOGY, 2000, 165 (05) :2528-2534

[84] Genetic deficiency of C3 as well as CNS-targeted expression of the complement inhibitor sCrry ameliorates experimental autoimmune uveoretinitis [J].

Read, RW ;

Szalai, AJ ;

Vogt, SD ;

McGwin, G ;

Barnum, SR .

EXPERIMENTAL EYE RESEARCH, 2006, 82 (03) :389-394

[85]

REID KBM, 1986, ESSAYS BIOCHEM, V22, P27

[86]

ROSENBAUM JT, 1984, INVEST OPHTH VIS SCI, V25, P1184

[87] SUB-RETINAL NEOVASCULARIZATION - NATURAL-HISTORY OF AN EXPERIMENTAL-MODEL [J].

RYAN, SJ .

ARCHIVES OF OPHTHALMOLOGY, 1982, 100 (11) :1804-1809

[88] Estimation of systemic complement C3 activity in age-related macular degeneration [J].

Sivaprasad, Sobha ;

Adewoyin, Temi ;

Bailey, Tracey A. ;

Dandekar, Sam S. ;

Jenkins, Sharon ;

Webster, Andrew R. ;

Chong, Ngaihang Victor .

ARCHIVES OF OPHTHALMOLOGY, 2007, 125 (04) :515-519

[89] Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells [J].

Sohn, JH ;

Bora, PS ;

Suk, HJ ;

Molina, H ;

Kaplan, HJ ;

Bora, NS .

NATURE MEDICINE, 2003, 9 (02) :206-212

[90]

Sohn JH, 2000, INVEST OPHTH VIS SCI, V41, P3492

← 1 2 3 4 5 6 7 8 9 10 →