A New Method for Aromatic Difluoromethylation: Copper-Catalyzed Cross-Coupling and Decarboxylation Sequence from Aryl Iodides

被引：285
作者：
Fujikawa, Kenichi [1 ]
Fujioka, Yasutaka [1 ]
Kobayashi, Akira [2 ]
Amii, Hideki [1 ,2 ]
机构：
[1] Kobe Univ, Grad Sch Sci, Dept Chem, Kobe, Hyogo 6578501, Japan
[2] Gunma Univ, Dept Chem & Chem Biol, Grad Sch Engn, Gunma 3768515, Japan
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 20期
关键词：
MEDIATED FLUOROALKYLATION REACTIONS; OXIDATIVE TRIFLUOROMETHYLATION; REDUCTIVE ELIMINATION; BOND-FORMATION; PALLADIUM; ACIDS; BROMODIFLUOROACETATE; FLUORINATION; REACTIVITY; INHIBITORS;
D O I：
10.1021/ol202289z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new methodology for aromatic difluoromethylation is described. Aryl iodides reacted with alpha-silyldifluoroacetates upon treatment with copper catalyst in DMSO or DME to give the corresponding aryldifluoroacetates in moderate to good yields. The subsequent hydrolysis of aryldifluoroacetates and KF-promoted decarboxylation afforded a variety of difluoromethyl aromatics.
引用
收藏
页码：5560 / 5563
页数：4
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