Photothermal amplified cathodic ZnO quantum dots/Ru(bpy)32/S2O82- ternary system for ultrasensitive electrochemiluminescence detection of thyroglobulin

被引:37
作者
Fang, Dandan [1 ]
Ren, Huizhu [1 ]
Huang, Yitian [1 ]
Dai, Hong [1 ]
Huang, Defu [2 ]
Lin, Yanyu [1 ]
机构
[1] Fujian Normal Univ, Coll Chem & Mat, Fuzhou 350108, Fujian, Peoples R China
[2] Fujian Med Univ, Mengchao Hepatobiliary Hosp, Fuzhou 350025, Fujian, Peoples R China
来源
SENSORS AND ACTUATORS B-CHEMICAL | 2020年 / 312卷
基金
美国国家科学基金会;
关键词
ZnO quantum dots; Nb(2)CTx MXene; Photothermal amplification; ECL immunosensor; Coreactant accelerator; RESONANCE ENERGY-TRANSFER; TI3C2; MXENE; CARBON; BIOSENSOR; ACID; PLATFORM; ASSAY; DOTS;
D O I
10.1016/j.snb.2020.127950
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Herein, an ultrasensitive electrochemiluminescence (ECL) immunosensor based on a high performance probe of Nb(2)CTx MXene immobilized ZnO quantum dots (QDs) was constructed for Thyroglobulin (Tg) detection. ZnO QDs with good biocompatibility and catalytic property was for the first time utilized as coreaction accelerator in Ru(bpy)(3)(2+)/S2O82- system and enhanced ECL signal. Specifically, ZnO QDs can facilitate S2O82- reduction to generate more SO4 center dot-. and then reacted with cathodic radical of Ru(bpy)(3)(2+), realizing 2-fold enhancement in ECL intensity. Additionally, Nb(2)CTx MXene possesses excellent properties and was used as prominent supporter, improving the loading capacity of Ru(bpy)(3)(2+) and ZnO QDs, and accelerating the electron transfer, resulting in ECL signal enhancement. Furthermore, Nb(2)CTx MXene acted as temperature controller and increased the electrode surface temperature by converting laser energy into heat, further amplified ECL signal. Because of the high sensitivity, good specificity and favorable stability, the proposed immunosensor realized sensitive detection of Thyroglobulin and had a great application prospect in bioanalysis and clinical diagnosis.
引用
收藏
页数:7
相关论文
共 34 条
[1]   The synergetic effects of Ti3C2 MXene and Pt as co-catalysts for highly efficient photocatalytic hydrogen evolution over g-C3N4 [J].
An, Xiaoqiang ;
Wang, Wei ;
Wang, Jiangpeng ;
Duan, Haozhi ;
Shi, Jintao ;
Yu, Xuelian .
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2018, 20 (16) :11405-11411
[2]   Disposable biosensor based on cathodic electrochemiluminescence of tris(2,2-bipyridine)ruthenium(II) for uric acid determination [J].
Ballesta-Claver, J. ;
Rodriguez-Gomez, R. ;
Capitan-Vallvey, L. F. .
ANALYTICA CHIMICA ACTA, 2013, 770 :153-160
[3]   New capillary electrophoresis-electrochemiluminescence detection system equipped with an electrically heated Ru(bpy)32+/multi-wall-carbon-nanotube paste electrode [J].
Chen, Yiting ;
Lin, Zhenyu ;
Chen, Jinhua ;
Sun, Jianjun ;
Zhang, Lan ;
Chen, Guonan .
JOURNAL OF CHROMATOGRAPHY A, 2007, 1172 (01) :84-91
[4]   A microfluidic biosensor based on competitive protein adsorption for thyroglobulin detection [J].
Choi, Seokheun ;
Chae, Junseok .
BIOSENSORS & BIOELECTRONICS, 2009, 25 (01) :118-123
[5]   Thermal characteristics of temperature-controlled electrochemical microdevices [J].
Contento, Nicholas M. ;
Semancik, Steve .
SENSORS AND ACTUATORS B-CHEMICAL, 2016, 225 :279-287
[6]   An electrochemical sensing platform structured with carbon nanohorns for detecting some food borne contaminants [J].
Dai, Hong ;
Gong, Lingshan ;
Xu, Guifang ;
Zhang, Shupei ;
Lu, Shuanyan ;
Jiang, Yuwei ;
Lin, Yanyu ;
Guo, Longhua ;
Chen, Guonan .
ELECTROCHIMICA ACTA, 2013, 111 :57-63
[7]   Photothermal enhanced enzymatic activity of lipase covalently immobilized on functionalized Ti3C2TX nanosheets [J].
Ding, Chaoying ;
Liang, Junmei ;
Zhou, Zhou ;
Li, Yang ;
Peng, Wenchao ;
Zhang, Guoliang ;
Zhang, Fengbao ;
Fan, Xiaobin .
CHEMICAL ENGINEERING JOURNAL, 2019, 378
[8]   Indirect detection of alcoholic strength in spirits by fluorescence method using the polyethyleneimine capped ZnO QDs [J].
Geng, Shou ;
Lin, Shu Min ;
Liu, Shi Gang ;
Zhang, Wei ;
Li, Nian Bing ;
Luo, Hong Qun .
SENSORS AND ACTUATORS B-CHEMICAL, 2016, 236 :591-596
[9]   Photoassisted Synthesis of Luminescent Mannose-Au Nanodots for the Detection of Thyroglobulin in Serum [J].
Huang, Chih-Ching ;
Hung, Yu-Lun ;
Shiang, Yen-Chun ;
Lin, Tai-Yuan ;
Lin, Yu-Shen ;
Chen, Chao-Tsen ;
Chang, Huan-Tsung .
CHEMISTRY-AN ASIAN JOURNAL, 2010, 5 (02) :334-341
[10]   Regulable preparation of the oxygen vacancy of ZnO QDs and their fluorescence performance [J].
Huang, Wenyi ;
Lv, Xiaowei ;
Tan, Jialin ;
Huang, Qiumei ;
Cheng, Hao ;
Feng, Jun ;
Li, Lijun .
JOURNAL OF MOLECULAR STRUCTURE, 2019, 1195 :653-658