Towards a cellular pathophysiology of Meniere's disease

被引：0

作者：

Düwel, P

Walther, LE

Haasler, T

Westhofen, M

Lückhoff, A

机构：

[1] Klinik für HNO, Universitätsklinikum der RWTH Aachen

[2] Institut für Physiologie, RWTH Aachen

[3] Klinik für Hals-, Nasen- und Ohrenheilkunde und Plastische Kopf- und Halschirurgie, Universitätsklinikum Aachen, 52057 Aachen

来源：

LARYNGO-RHINO-OTOLOGIE | 2005年 / 84卷 / 06期

关键词：

Calcium; Dizziness; Hair cell; Hydrops; Menière's disease; Physiology; Potassium; Therapy; Vertigo; Vestibular;

D O I：

10.1055/s-2005-861120

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background: A modest increase in the hydrostatic pressure within the endolymphatic space may induce an endolymphatic hydrops which in turn is typically associated with Menière's disease. However, there is no convincing pathophysiological model that might explain, on a cellular level, how a pressure increases may cause disturbed functions of vestibular hair cells and vertigo attacks. Methods: So far, models involve osmotic mechanisms leading to electrolyte imbalances in the endolymphatic space. Alternatively, impaired longitudinal flow in the endolymphatic space is considered important. Results: Recently, a pressure-sensitive potassium current was identified and characterized in vestibular hair cells. Conclusions: This current may modify the frequency behavior of a cell and may be the missing link" in a cellular pathophysiology of the hydrops. Ion currents in hair cells offer attractive targets for pharmacological interventions in Menière's disease. © Georg Thieme Verlag KG Stuttgart."

引用

页码：412 / 417

页数：6

共 34 条

[1]

Meniere P., Sur une forme particulière de surdité grave dépendant d'une lésion de l'oreille interne, Gazette Médicale de Paris, 16, (1861)

[2]

Tsutsumi T., Kobayashi M., Koda H., Kitamura K., Clinical characteristics of audio-vestibular impairment in Menière's disease: Does vestibular function deteriorate in accordance with cochlear function?, Acta Otolaryngol, 123, pp. 396-400, (2003)

[3]

Paparella M.M., Pathogenesis of Menière's disease: Treatment considerations. Preface, Otolaryngol Clin North Am, 35, (2002)

[4]

Perez F.N., Perez G.H., Antoli C.F., Garcia I.E., Menière's disease: Diagnostic criteria, criteria to establish stages, and standards for treatment evaluation. Bibliographic review and update, Acta Otorrinolaringol Esp, 53, pp. 621-626, (2002)

[5]

Paparella M.M., Pathogenesis of Menière's disease: Treatment considerations. Preface, Otolaryngol Clin North Am, 35, (2002)

[6]

Watanabe Y., Mizukoshi K., Shojaku H., Watanabe I., Hinoki M., Kitahara M., Epidemiological and clinical characteristics of Menière's disease in Japan, Acta Otolaryngol Suppl, 519, pp. 206-210, (1995)

[7]

Kotimaki J., Sorri M., Aantaa E., Nuutinen J., Prevalence of Menière disease in Finland, Laryngoscope, 109, pp. 748-753, (1999)

[8]

Lee H., Lopez I., Ishiyama A., Baloh R.W., Can migraine damage the inner ear?, Arch Neurol, 57, pp. 1631-1634, (2000)

[9]

Parker W., Menière's disease. Etiologic considerations, Arch Otolaryngol Head Neck Surg, 121, pp. 377-382, (1995)

[10]

Dornhoffer J.L., Danner C., Zhou L., Li S., Atrial natriuretic peptide receptor upregulation in the rat inner ear, Ann Otol Rhinol Laryngol, 111, pp. 1040-1044, (2002)

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