Transplacental passage of a nonionic contrast agent

被引：21

作者：

Vanhaesebrouck, P

Verstraete, AG

De Praeter, C

Smets, K

Zecic, A

Craen, M

机构：

[1] Ghent Univ Hosp, Dept Neonatol, B-9000 Ghent, Belgium

[2] Ghent Univ Hosp, Dept Clin Biochem, B-9000 Ghent, Belgium

[3] Ghent Univ Hosp, Dept Paediat Endocrinol, B-9000 Ghent, Belgium

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 2005年 / 164卷 / 07期

关键词：

iopromide; nonionic monomer; thyroid; transplacental passage; urinary iodine;

D O I：

10.1007/s00431-005-1659-2

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We report the presence of iopromide in the bowel and urine of a preterm infant, born 10 days after intravenous administration of the nonionic monomer to his mother. Excessive urinary iodine excretion and borderline hyperthyrotropinaemia were observed in the infant. Moreover, crossing of the fetal blood-brain barrier was demonstrated by detection of the angiographic material in CSF and thus direct fetal neurotoxic effects cannot be excluded. Conclusion:These widely used contrast media may cross the placenta and accumulate in various fetal tissues in significant amounts causing possible neonatal toxicity. Therefore the perinatal safety of these diagnostic agents should at least be questioned.

引用

收藏

页码：408 / 410

页数：3

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