Advances in Multi-Omics Study of Prognostic Biomarkers of Diffuse Large B-Cell Lymphoma

被引：25
作者：
Liang, Xiao-jie [1 ]
Song, Xin-yu [2 ]
Wu, Jia-lin [3 ]
Liu, Dan [2 ]
Lin, Bing-yu [2 ]
Zhou, Hong-sheng [1 ]
Wang, Liang [4 ]
机构：
[1] Southern Med Univ, Nanfang Hosp, Dept Hematol, Guangzhou 510515, Peoples R China
[2] Guangdong Med Univ, Clin Med Coll 1, Zhanjiang 524000, Peoples R China
[3] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Intervent Radiol, Guangzhou 510630, Peoples R China
[4] Capital Med Univ, Beijing Tongren Hosp, Dept Hematol, Beijing 100730, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2022年 / 18卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Diffuse large B cell lymphoma; Prognosis; Precision medicine; Systems biology; Biomarkers; CIRCULATING TUMOR DNA; FREE LIGHT-CHAINS; CEREBROSPINAL-FLUID; RESPONSE ASSESSMENT; CNS RELAPSE; SURVIVAL; EXPRESSION; GENOME; RISK; MYC;
D O I：
10.7150/ijbs.67892
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
As the most common subtype of non-Hodgkin's lymphoma, diffuse large B-cell lymphoma (DLBCL) is characterized by a huge degree of clinical and prognostic heterogeneity. Currently, there is an urgent need for highly specific and sensitive biomarkers to predict the therapeutic response of DLBCL and assess which patients can benefit from systemic chemotherapy to help develop more precise therapeutic regimens for DLBCL. Systems biology (holistic study of diseases) is more comprehensive in quantifying and identifying biomarkers, helps addressing major biological problems, and possesses high accuracy and sensitivity. In this article, we provide an overview of research advances in DLBCL prognostic biomarkers made using the multi-omics approach of genomics, transcriptomics, epigenetics, proteomics, metabonomics, radiomics, and the currently developing single-cell technologies.
引用
收藏
页码：1313 / 1327
页数：15
相关论文
共 108 条
[61]   Inhibition of B Cell Receptor Signaling by Ibrutinib in Primary CNS Lymphoma [J].
Lionakis, Michail S. ;
Dunleavy, Kieron ;
Roschewski, Mark ;
Widemann, Brigitte C. ;
Butman, John A. ;
Schmitz, Roland ;
Yang, Yandan ;
Cole, Diane E. ;
Melani, Christopher ;
Higham, Christine S. ;
Desai, Jigar V. ;
Ceribelli, Michele ;
Chen, Lu ;
Thomas, Craig J. ;
Little, Richard F. ;
Gea-Banacloche, Juan ;
Bhaumik, Sucharita ;
Stetler-Stevenson, Maryalice ;
Pittaluga, Stefania ;
Jaffe, Elaine S. ;
Heiss, John ;
Lucas, Nicole ;
Steinberg, Seth M. ;
Staudt, Louis M. ;
Wilson, Wyndham H. .
CANCER CELL, 2017, 31 (06) :833-+
[62]  
Lue KH., 2020, DIAGNOSTICS, P11
[63]   Clinical Impact of the 2016 Update to the WHO Lymphoma Classification [J].
Lynch, Ryan C. ;
Gratzinger, Dita ;
Advani, Ranjana H. .
CURRENT TREATMENT OPTIONS IN ONCOLOGY, 2017, 18 (07)
[64]   Final Results of a Prospective Evaluation of the Predictive Value of Interim Positron Emission Tomography in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP-14 (SAKK 38/07) [J].
Mamot, Christoph ;
Klingbiel, Dirk ;
Hitz, Felicitas ;
Renner, Christoph ;
Pabst, Thomas ;
Driessen, Christoph ;
Mey, Ulrich ;
Pless, Miklos ;
Bargetzi, Mario ;
Krasniqi, Fatime ;
Gigli, Federica ;
Hany, Thomas ;
Samarin, Andrei ;
Biaggi, Christine ;
Rusterholz, Corinne ;
Dirnhofer, Stephan ;
Zucca, Emanuele ;
Martinelli, Giovanni .
JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (23) :2523-U63
[65]   Pathophysiological significance and therapeutic targeting of germinal center kinase in diffuse large B-cell lymphoma [J].
Matthews, Julie Marie ;
Bhatt, Shruti ;
Patricelli, Matthew P. ;
Nomanbhoy, Tyzoon K. ;
Jiang, Xiaoyu ;
Natkunam, Yasodha ;
Gentles, Andrew J. ;
Martinez, Ezequiel ;
Zhu, Daxing ;
Chapman, Jennifer Rose ;
Cortizas, Elena ;
Shyam, Ragini ;
Chinichian, Shideh ;
Advani, Ranjana ;
Tan, Li ;
Zhang, Jianming ;
Choi, Hwan Geun ;
Tibshirani, Robert ;
Buhrlage, Sara J. ;
Gratzinger, Dita ;
Verdun, Ramiro ;
Gray, Nathanael S. ;
Lossos, Izidore S. .
BLOOD, 2016, 128 (02) :239-248
[66]   Elevated Serum Free Light Chains Are Associated With Event-Free and Overall Survival in Two Independent Cohorts of Patients With Diffuse Large B-Cell Lymphoma [J].
Maurer, Matthew J. ;
Micallef, Ivana N. M. ;
Cerhan, James R. ;
Katzmann, Jerry A. ;
Link, Brian K. ;
Colgan, Joseph P. ;
Habermann, Thomas M. ;
Inwards, David J. ;
Markovic, Svetomir N. ;
Ansell, Stephen M. ;
Porrata, Luis F. ;
Johnston, Patrick B. ;
Nowakowski, Grzegorz S. ;
Thompson, Carrie A. ;
Gupta, Mamta ;
Syrbu, Sergei I. ;
Kurtin, Paul J. ;
Macon, William R. ;
Nikcevich, Daniel A. ;
Witzig, Thomas E. .
JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (12) :1620-1626
[67]   Low Expression and Somatic Mutations of the KLHL6 Gene Predict Poor Survival in Patients with Activated B-Cell like Diffuse Large B-Cell Lymphoma [J].
Meriranta, Leo ;
Pasanen, Annika ;
Cervera, Alejandra ;
Holte, Harald, Jr. ;
Lehtonen, Rainer ;
Hautaniemi, Sampsa ;
Leppa, Sirpa .
BLOOD, 2016, 128 (22)
[68]   Genetic alterations and their clinical implications in DLBCL [J].
Miao, Yi ;
Medeiros, L. Jeffrey ;
Li, Yong ;
Li, Jianyong ;
Young, Ken H. .
NATURE REVIEWS CLINICAL ONCOLOGY, 2019, 16 (10) :634-652
[69]   Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response [J].
Monti, S ;
Savage, KJ ;
Kutok, JL ;
Feuerhake, F ;
Kurtin, P ;
Mihm, M ;
Wu, BY ;
Pasqualucci, L ;
Neuberg, D ;
Aguiar, RCT ;
Dal Cin, P ;
Ladd, C ;
Pinkus, GS ;
Salles, G ;
Harris, NL ;
Dalla-Favera, R ;
Habermann, TM ;
Aster, JC ;
Golub, TR ;
Shipp, MA .
BLOOD, 2005, 105 (05) :1851-1861
[70]   Contribution of cerebrospinal fluid sCD19 levels to the detection of CNS lymphoma and its impact on disease outcome [J].
Muniz, Carmen ;
Martin-Martin, Lourdes ;
Lopez, Antonio ;
Sanchez-Gonzalez, Blanca ;
Salar, Antonio ;
Almeida, Julia ;
Sancho, Juan-Manuel ;
Maria Ribera, Jose ;
Heras, Cecilia ;
Javier Penalver, Francisco ;
Gomez, Marta ;
Gonzalez-Barca, Eva ;
Alonso, Natalia ;
Navarro, Belen ;
Olave, Teresa ;
Sala, Francisco ;
Conde, Eulogio ;
Antonio Marquez, Jose ;
Cabezudo, Elena ;
Cladera, Antonia ;
Garcia-Malo, Maria ;
Dolores Caballero, Maria ;
Orfao, Alberto .
BLOOD, 2014, 123 (12) :1864-1869
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