Advances in Multi-Omics Study of Prognostic Biomarkers of Diffuse Large B-Cell Lymphoma

被引：25

作者：

Liang, Xiao-jie ^{[1
]}

Song, Xin-yu ^{[2
]}

Wu, Jia-lin ^{[3
]}

Liu, Dan ^{[2
]}

Lin, Bing-yu ^{[2
]}

Zhou, Hong-sheng ^{[1
]}

Wang, Liang ^{[4
]}

机构：

[1] Southern Med Univ, Nanfang Hosp, Dept Hematol, Guangzhou 510515, Peoples R China

[2] Guangdong Med Univ, Clin Med Coll 1, Zhanjiang 524000, Peoples R China

[3] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Intervent Radiol, Guangzhou 510630, Peoples R China

[4] Capital Med Univ, Beijing Tongren Hosp, Dept Hematol, Beijing 100730, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2022年 / 18卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Diffuse large B cell lymphoma; Prognosis; Precision medicine; Systems biology; Biomarkers; CIRCULATING TUMOR DNA; FREE LIGHT-CHAINS; CEREBROSPINAL-FLUID; RESPONSE ASSESSMENT; CNS RELAPSE; SURVIVAL; EXPRESSION; GENOME; RISK; MYC;

D O I：

10.7150/ijbs.67892

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As the most common subtype of non-Hodgkin's lymphoma, diffuse large B-cell lymphoma (DLBCL) is characterized by a huge degree of clinical and prognostic heterogeneity. Currently, there is an urgent need for highly specific and sensitive biomarkers to predict the therapeutic response of DLBCL and assess which patients can benefit from systemic chemotherapy to help develop more precise therapeutic regimens for DLBCL. Systems biology (holistic study of diseases) is more comprehensive in quantifying and identifying biomarkers, helps addressing major biological problems, and possesses high accuracy and sensitivity. In this article, we provide an overview of research advances in DLBCL prognostic biomarkers made using the multi-omics approach of genomics, transcriptomics, epigenetics, proteomics, metabonomics, radiomics, and the currently developing single-cell technologies.

引用

页码：1313 / 1327

页数：15

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