The multiple facets of toll-like receptors in transplantation biology

被引：58
作者：
Alegre, Maria-Luisa [2 ]
Leemans, Jaklien [3 ]
Le Moine, Alain [1 ]
Florquin, Sandrine [3 ]
De Wilde, Virginie [1 ]
Chong, Anita [4 ]
Goldman, Michel [1 ]
机构：
[1] Univ Libre Bruxelles, Inst Med immunol, B-6041 Charleroi, Belgium
[2] Univ Chicago, Dept Med, Rheumatol Sect, Chicago, IL 60637 USA
[3] Univ Amsterdam, Acad Med Ctr, Dept Pathol, NL-1105 AZ Amsterdam, Netherlands
[4] Univ Chicago, Dept Surg, Sect Transplantat, Chicago, IL 60637 USA
来源：
TRANSPLANTATION | 2008年 / 86卷 / 01期
关键词：
toll-like receptors; ischemia-reperfusion; acute rejection; T cells;
D O I：
10.1097/TP.0b013e31817c11e6
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Toll-like receptors (TLRs) belong to a family of pattern-recognition receptors for microbial products and endogenous molecules released by stressed cells. Experimental studies show that TLRs are involved in the process of acute allograft rejection and that their activation can prevent transplantation tolerance. Herein, we review the expression of TLRs and the impact of TLR signaling in different cell types in grafted organs including antigen-presenting cells, T and B lymphocytes, epithelial and endothelial cells. We then discuss the involvement of TLRs in the different phases of the rejection phenomenon and the impact of TLR-mediated events on regulatory circuits which dampen alloimmune responses.
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页码：1 / 9
页数：9
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