Serum inhibin B levels before and after varicocelectomy in early adolescence

被引:7
作者
Cavarzere, P. [1 ]
Sulpasso, M. [2 ]
Maines, E.
Vincenzi, M.
Gaudino, R.
Monti, E.
Chironi, C. [2 ]
Tato, L.
Antoniazzi, F.
机构
[1] Univ Verona, Dept Life & Reprod Sci, Policlin GB Rossi, Div Pediat, I-37134 Verona, Italy
[2] Hosp Peschiera, Div Pediat Surg, Verona, Italy
来源
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 2011年 / 34卷 / 09期
关键词
Inhibin B; varicocele; adolescence; varicocelectomy; PUBERTAL BOYS; MEN; SPERMATOGENESIS; TESTOSTERONE; PARAMETERS; FERTILITY; CHILDREN; HORMONE; REPAIR; TESTES;
D O I
10.3275/7796
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Whereas no clear relationship has been observed between varicocelectomy and serum inhibin B levels in men, in adolescents comparison between inhibin B levels before and after varicocelectomy is lacking. Aim: To evaluate the effect of varicocele surgical treatment on inhibin B levels in adolescents at the beginning of puberty compared to a group of healthy adolescents. Subjects and methods: We studied 28 adolescents in Tanner 2 pubertal stage with a grade III left-sided varicocele (patients) compared to 13 age- and pubertal stage-matched healthy adolescents (controls). All patients underwent blood tests to determine serum inhibin B levels before and 6 months after varicocelectomy by Palomo procedure. For comparison we investigated inhibin B levels in controls and repeated this test 6 months later. Testicular ultrasound was performed for patients only. Results: Baseline inhibin B concentrations of patients and controls were 109.90 +/- 40.26 and 109.33 +/- 38.34 pg/ml, respectively. No significant changes were observed in patients' inhibin El concentrations after varicocelectomy (116.00 +/- 42.65 pg/ml), or in controls during the 6 months' follow-up (99.12 +/- 30.09 pg/ml). Doppler examination after treatment shows a complete resolution of varicocele in all the patients without alterations in testicular parenchyma. Conclusions: Varicocelectomy pm-formed on adolescents at T2 pubertal stage might be useful to avoid alteration in inhibin B production and consequently in testicular function. Further studies are necessary to confirm the prognostic value of inhibin B levels and the benefit of early varicocelectomy in preserving the fertility of these adolescents. (J. Endocrinol. Invest. 34: e265-e267, 2011) (C) 2011, Editrice Kurtis
引用
收藏
页码:E265 / E267
页数:3
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