The many lives of IL-9: a question of survival?

被引：64

作者：

Wilhelm, Christoph ^{[1
]}

Turner, Jan-Eric ^{[1
]}

Van Snick, Jacques ^{[2
,3
]}

Stockinger, Brigitta ^{[1
]}

机构：

[1] Natl Inst Med Res, MRC, Div Mol Immunol, London NW7 1AA, England

[2] Univ Louvain, Christian Duve Inst Cellular Pathol, Ludwig Inst Canc Res, Brussels Branch, Brussels, Belgium

[3] Univ Louvain, Christian Duve Inst Cellular Pathol, Ludwig Inst Canc Res, Expt Med Unit, Brussels, Belgium

来源：

NATURE IMMUNOLOGY | 2012年 / 13卷 / 07期

基金：

英国医学研究理事会;

关键词：

LUNG EPITHELIAL-CELLS; T-CELLS; GROWTH-FACTOR; AIRWAY INFLAMMATION; TGF-BETA; EXPRESSION CLONING; INTERLEUKIN-9; DIFFERENTIATION; INDUCTION; RECEPTOR;

D O I：

10.1038/ni.2303

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although the cytokine interleukin 9 (IL-9) was discovered decades ago, it remains one of the most enigmatic cytokines identified so far, in particular because its functional activities remain far from clear. Breakthroughs made through the use of IL-9 reporter mice have allowed the identification of cell types that produce IL-9 in vivo and, contrary to expectations based on previous results obtained in vitro, it is not T cells but instead a previously unknown type of innate lymphoid cell, called the 'ILC2 cell', that is the main cell type that expresses IL-9 in vivo. In this perspective, we put forward a hypothesis about the potential biological functions of IL-9 in the immune system and beyond.

引用

页码：637 / 641

页数：5

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