A Hydrophobic Starch Polymer for Nanoparticle-Mediated Delivery of Docetaxel

被引：46

作者：

Dandekar, Prajakta ^{[1
,2
]}

Jain, Ratnesh ^{[1
,2
]}

Stauner, Thomas

Loretz, Brigitta ^{[1
,2
]}

Koch, Marcus ^{[3
]}

Wenz, Gerhard

Lehr, Claus-Michael ^{[1
,2
]}

机构：

[1] Univ Saarland, Dept Drug Delivery DDEL, Helmholtz Inst Pharmaceut Res Saarland HIPS, D-66123 Saarbrucken, Germany

[2] Univ Saarbrucken, Dept Biopharmaceut & Pharmaceut, D-66123 Saarbrucken, Germany

[3] Univ Saarland, Leibniz Inst New Mat, Serv Grp Phys Anal, D-66123 Saarbrucken, Germany

来源：

MACROMOLECULAR BIOSCIENCE | 2012年 / 12卷 / 02期

关键词：

biological applications of polymers; cytotoxicity; docetaxel; nanoparticles; propyl starch; LOADED NANOPARTICLES; DRUG-DELIVERY; RELEASE; PHARMACOKINETICS; NANOSPHERES; PACLITAXEL; EFFICACY;

D O I：

10.1002/mabi.201100244

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A hydrophobic starch derivative is used for safe and enhanced delivery of anticancer agents. The synthesis and characterization of propyl starch with a controlled degree of substitution to modulate the release of the encapsulated hydrophobic drug is reported. The application of this polymer for formulating nanoparticles of docetaxel, an anti-cancer agent effective against numerous types of cancers but possessing intrinsic formulation difficulties is described. The solvent emulsification/diffusion technique is used and the synthesis is optimized with respect to several formulation parameters. Uptake studies with these nanoparticles indicate their enhanced internalization by the cancerous cells and their peri-nuclear localization.

引用

页码：184 / 194

页数：11

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