The NF-κB Pathway and Cancer Stem Cells

被引：207
作者：
Rinkenbaugh, Amanda L. [1 ,2 ]
Baldwin, Albert S. [2 ]
机构：
[1] Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
来源：
CELLS | 2016年 / 5卷 / 02期
关键词：
NF-kappa B; cancer; cancer stem cells; tumor-initiating cells; self-renewal; EPITHELIAL-MESENCHYMAL TRANSITION; GLIOBLASTOMA-INITIATING CELLS; TRANSCRIPTIONAL UP-REGULATION; TUMOR-ASSOCIATED MACROPHAGES; NUCLEAR EXPORT SIGNAL; HEMATOPOIETIC STEM; PROSPECTIVE IDENTIFICATION; NEUROBLASTOMA-CELLS; ALTERNATIVE PATHWAY; MEDIATED INDUCTION;
D O I：
10.3390/cells5020016
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The NF-kappa B transcription factor pathway is a crucial regulator of inflammation and immune responses. Additionally, aberrant NF-kappa B signaling has been identified in many types of cancer. Downstream of key oncogenic pathways, such as RAS, BCR-ABL, and Her2, NF-kappa B regulates transcription of target genes that promote cell survival and proliferation, inhibit apoptosis, and mediate invasion and metastasis. The cancer stem cell model posits that a subset of tumor cells (cancer stem cells) drive tumor initiation, exhibit resistance to treatment, and promote recurrence and metastasis. This review examines the evidence for a role for NF-kappa B signaling in cancer stem cell biology.
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页数：19
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共 180 条
[1]   Ibrutinib and novel BTK inhibitors in clinical development [J].
Akinleye, Akintunde ;
Chen, Yamei ;
Mukhi, Nikhil ;
Song, Yongping ;
Liu, Delong .
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2013, 6
[2]   Prospective identification of tumorigenic breast cancer cells [J].
Al-Hajj, M ;
Wicha, MS ;
Benito-Hernandez, A ;
Morrison, SJ ;
Clarke, MF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988
[3]   Stem-Like Ovarian Cancer Cells Can Serve as Tumor Vascular Progenitors [J].
Alvero, Ayesha B. ;
Fu, Han-Hsuan ;
Holmberg, Jennie ;
Visintin, Irene ;
Mor, Liora ;
Marquina, Carlos Cano ;
Oidtman, Jessica ;
Silasi, Dan-Arin ;
Mor, Gil .
STEM CELLS, 2009, 27 (10) :2405-2413
[4]   Mechanism of von Hippel-Lindau protein-mediated suppression of nuclear factor kappa B activity [J].
An, JB ;
Rettig, MB .
MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (17) :7546-7556
[5]   VHL expression in renal cell carcinoma sensitizes to bortezomib (PS-341) through an NF-κB-dependent mechanism [J].
An, JB ;
Fisher, M ;
Rettig, MB .
ONCOGENE, 2005, 24 (09) :1563-1570
[6]   The role of PI3K/AKT, MAPK/ERK and NFκβ signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis [J].
Armstrong, Lyle ;
Hughes, Owen ;
Yung, Sun ;
Hyslop, Louise ;
Stewart, Rebecca ;
Wappler, Ilka ;
Peters, Heiko ;
Walter, Theresia ;
Stojkovic, Petra ;
Evans, Jerome ;
Stojkovic, Miodrag ;
Lako, Majlinda .
HUMAN MOLECULAR GENETICS, 2006, 15 (11) :1894-1913
[7]   The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-κB and c-Myc in pancreatic cancer cells [J].
Asano, T ;
Yao, YX ;
Zhu, JJ ;
Li, DH ;
Abbruzzese, JL ;
Reddy, SAG .
ONCOGENE, 2004, 23 (53) :8571-8580
[8]   AXL induces epithelial-to-mesenchymal transition and regulates the function of breast cancer stem cells [J].
Asiedu, M. K. ;
Beauchamp-Perez, F. D. ;
Ingle, J. N. ;
Behrens, M. D. ;
Radisky, D. C. ;
Knutson, K. L. .
ONCOGENE, 2014, 33 (10) :1316-1324
[9]   IKK/NF-κB regulates skeletal myrogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis [J].
Bakkar, Nadine ;
Wang, Jingxin ;
Ladner, Katherine J. ;
Wang, Huating ;
Dahlman, Jason M. ;
Carathers, Micheal ;
Acharyya, Swarnali ;
Rudnicki, Michael A. ;
Hollenbach, Andrew D. ;
Guttridge, Denis C. .
JOURNAL OF CELL BIOLOGY, 2008, 180 (04) :787-802
[10]   Regulation of cell death and autophagy by IKK and NF-κB: critical mechanisms in immune function and cancer [J].
Baldwin, Albert S. .
IMMUNOLOGICAL REVIEWS, 2012, 246 :327-345
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