Structure-activity relationship studies of the chromosome segregation inhibitor, Incentrom A

被引：8
作者：
Lee, Hee-Yoon [1 ,2 ]
Jung, Yongsik [1 ,2 ]
Kim, Wonyeob [1 ,2 ]
Kim, Jin Hee [3 ]
Suh, Min-Soo [3 ]
Shin, Seung Koo [3 ]
Yoon, Hye-Joo [3 ]
机构：
[1] Korea Adv Inst Sci & Technol, Dept Chem, Taejon 305701, South Korea
[2] Korea Adv Inst Sci & Technol, Sch Mol Sci BK21, Taejon 305701, South Korea
[3] Pohang Univ Sci & Technol, Dept Chem, Bionanotechnol Ctr, Pohang 790784, Kyungbuk, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 16期
关键词：
inhibition; chromosome segregation; yeast; structure-activity relationship; pharmacophore; incentrom A;
D O I：
10.1016/j.bmcl.2008.07.006
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of Incentrom A analogs that inhibit the chromosome segregation process in yeast were synthesized and tested for their effects on chromosome stability and cell proliferation. Pharmacophore and structure-activity relationship of Incentrom A for the anti-yeast activity were established. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4670 / 4674
页数：5
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