Structure-activity relationship studies of the chromosome segregation inhibitor, Incentrom A

被引：8
|
作者：
Lee, Hee-Yoon [1 ,2 ]
Jung, Yongsik [1 ,2 ]
Kim, Wonyeob [1 ,2 ]
Kim, Jin Hee [3 ]
Suh, Min-Soo [3 ]
Shin, Seung Koo [3 ]
Yoon, Hye-Joo [3 ]
机构：
[1] Korea Adv Inst Sci & Technol, Dept Chem, Taejon 305701, South Korea
[2] Korea Adv Inst Sci & Technol, Sch Mol Sci BK21, Taejon 305701, South Korea
[3] Pohang Univ Sci & Technol, Dept Chem, Bionanotechnol Ctr, Pohang 790784, Kyungbuk, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 16期
关键词：
inhibition; chromosome segregation; yeast; structure-activity relationship; pharmacophore; incentrom A;
D O I：
10.1016/j.bmcl.2008.07.006
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of Incentrom A analogs that inhibit the chromosome segregation process in yeast were synthesized and tested for their effects on chromosome stability and cell proliferation. Pharmacophore and structure-activity relationship of Incentrom A for the anti-yeast activity were established. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4670 / 4674
页数：5
相关论文
共 50 条
  • [1] Structure-Activity Relationship of the Bitterness Inhibitor Ferulic Acid
    Fang, Zichao
    Zhou, Junhan
    Zheng, Jianxian
    Shipin Kexue/Food Science, 2024, 45 (14): : 14 - 22
  • [2] Structure-activity relationship studies of antiplasmodial aminomethylthiazoles
    Cheuka, Peter Mubanga
    Cabrera, Diego Gonzalez
    Paquet, Tanya
    Chibale, Kelly
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (22) : 5207 - 5211
  • [3] Studies on electronic structure and the structure-activity relationship of Brevetoxins (BTX)
    Chen, CY
    Feng, S
    Ding, XQ
    ACTA CHIMICA SINICA, 2000, 58 (07) : 799 - 804
  • [4] Structure-activity relationship studies on iezoside, a highly potent Ca2+ ATPase inhibitor
    Kurisawa, Naoaki
    Teranuma, Kazuya
    Noto, Akari
    Iwasaki, Arihiro
    Kabashima, Yoshiki
    Nakajima, Rie
    Toyoshima, Chikashi
    Suenaga, Kiyotake
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 2024, 97 (07)
  • [5] Studies on electronic structure and structure-activity relationship of ciguatoxin(CTX)
    Chen, CY
    Ding, XQ
    Feng, S
    ACTA PHYSICO-CHIMICA SINICA, 2000, 16 (04) : 307 - 311
  • [6] Studies on structure-activity relationship of epibatidine and its analogues
    Xu, JP
    He, D
    Wang, ZZ
    Shen, JC
    Gao, LX
    Song, YR
    CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 1996, 17 (12): : 1893 - 1895
  • [7] Truncated Orexin Peptides: Structure-Activity Relationship Studies
    German, Nadezhda A.
    Decker, Ann M.
    Gilmour, Brian P.
    Thomas, Brian F.
    Zhang, Yanan
    ACS MEDICINAL CHEMISTRY LETTERS, 2013, 4 (12): : 1224 - 1227
  • [8] Diarylpentanoids with antitumor activity: A critical review of structure-activity relationship studies
    Moreira, Joana
    Saraiva, Lucilia
    Pinto, Madalena M.
    Cidade, Honorina
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 192
  • [9] Synthetic and Structure-Activity Relationship Studies on Bioactive Natural Products
    Kuramochi, Kouji
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2013, 77 (03) : 446 - 454
  • [10] Bioinspired Total Synthesis and Structure-Activity Relationship Studies on Aplaminal
    Ohyoshi, Takayuki
    Zhao, Yiwen
    Akemoto, Kei
    Ishihara, Takuma
    Taniguchi, Ayaka
    Zhang, Menghua
    Kigoshi, Hideo
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 2022, 95 (08) : 1242 - 1249
12345