Biomimetic synthesis of grandione from demethylsalvicanol via hetero-Diels-Alder type dimerization and structure revision of grandione

被引：29

作者：

Aoyagi, Y

Takahashi, Y

Satake, Y

Fukaya, H

Takeya, K

Aiyama, R

Matsuzaki, T

Hashimoto, S

Shiina, T

Kurihara, T

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Hachioji, Tokyo 1920392, Japan

[2] Yakult Cent Inst Microbiol Res, Tokyo 1868650, Japan

[3] Josai Univ, Fac Sci, Sakado, Saitama 3500295, Japan

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 46期

关键词：

D O I：

10.1016/j.tetlet.2005.09.104

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Grandione, a unique isetexane diterpene dimer, was synthesized from demethylsalvicanol via the solid state hetero-Diels-Alder type dimerization reaction. By X-ray crystallography, grandione was determined to have the structure, in which the two isopropyl groups on the two monomer units are arranged syn. Grandione and some of its analogues showed a moderate cytotoxity on P388 murine leukemia cells. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：7885 / 7887

页数：3

共 7 条

[1] Grandione, a new heptacyclic dimeric diterpene from Torreya grandis Fort. [J].