From Whole-Brain Radiotherapy to Immunotherapy: A Multidisciplinary Approach for Patients with Brain Metastases from NSCLC

被引：14

作者：

Protopapa, Maria ^{[1
]}

Kouloulias, Vassilis ^{[2
]}

Nikoloudi, Styliani ^{[1
]}

Papadimitriou, Christos ^{[3
]}

Gogalis, Giannis ^{[1
]}

Zygogianni, Anna ^{[1
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Aretaie Univ Hosp, Med Sch, Radiat Oncol Unit,Dept Radiol 1, Athens, Greece

[2] Natl & Kapodistrian Univ Athens, Attikon Univ Gen Hosp, Med Sch, Radiat Oncol Unit,Dept Radiol 2, Athens, Greece

[3] Natl & Kapodistrian Univ Athens, Aretaie Univ Hosp Athens, Med Sch, Med Oncol Unit,Surg Clin 2, Athens, Greece

来源：

JOURNAL OF ONCOLOGY | 2019年 / 2019卷

关键词：

CELL-LUNG-CANCER; CENTRAL-NERVOUS-SYSTEM; POSTOPERATIVE STEREOTACTIC RADIOSURGERY; GRADED PROGNOSTIC ASSESSMENT; TYROSINE KINASE INHIBITORS; PROGRAMMED-DEATH; RADIATION-THERAPY; OPEN-LABEL; PHASE-III; SECONDARY ANALYSIS;

D O I：

10.1155/2019/3267409

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Non-small cell lung cancer patients with brain metastases have a multitude of treatment options, but there is currently no international and multidisciplinary consensus concerning their optimal treatment. Local therapies have the principal role, especially in symptomatic patients. Advances in surgery and radiation therapy manage considerable local control. Systemic treatments have shown effect in clinical trials and in real life clinical settings; yet, at present, this is restricted to patients with asymptomatic or stable intracranial lesions. Targeted agents can have a benefit only in patients with EGFR mutations or ALK rearrangement. Immunotherapy has shown impressive results in patients with PD-L1 expression in tumor cells. Its effects can be further enhanced by a synergy with radiotherapy, possibly by increasing the percentage of responders. The present review summarizes the need for more effective systemic treatments, so that the increased intracranial control achieved by local treatments can be translated in an increase in overall survival.

引用

页数：12

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