The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis

被引：747
作者：
Cardone, RA [1 ]
Casavola, V [1 ]
Reshkin, SJ [1 ]
机构：
[1] Univ Bari, Dept Gen & Environm Physiol, I-70126 Bari, Italy
来源：
NATURE REVIEWS CANCER | 2005年 / 5卷 / 10期
关键词：
D O I：
10.1038/nrc1713
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recent research has highlighted the fundamental role of the tumour's extracellular metabolic microenvironment in malignant invasion. This microenvironment is acidified primarily by the tumour-cell Na+/H+ exchanger NHE1 and the H+/lactate cotransporter, which are activated in cancer cells. NHE1 also regulates formation of invadopodia - cell structures that mediate tumour cell migration and invasion. How do these alterations of the metabolic microenvironment and cell invasiveness contribute to tumour formation and progression?
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页码：786 / 795
页数：10
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