A dual pH and redox-responsive Ag/AgO/carboxymethyl chitosan composite hydrogel for controlled dual drug delivery

被引：5

作者：

Xu, Yanqin ^{[1
]}

Liu, Jie ^{[1
]}

Guan, Shumin ^{[1
]}

Cao, Yuan ^{[1
]}

Chen, Changguo ^{[1
]}

Wang, Dan ^{[1
]}

机构：

[1] Chongqing Univ, Sch Chem & Chem Engn, Chongqing, Peoples R China

来源：

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | 2020年 / 31卷 / 13期

基金：

中国国家自然科学基金;

关键词：

Carboxymethyl chitosan; micelle; hydrogel; dual-response; drug release; SMART HYDROGEL; IN-VIVO; RELEASE; SYSTEM;

D O I：

10.1080/09205063.2020.1774118

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A pH and redox dual-responsive composite hydrogel was developed, which was formed from triblock copolymer PEG-SS-PCL-SS-PEG and Ag/AgO/carboxymethyl chitosan (CMCS) hydrogel inclusion complexes. Dithiodipropionic acid and poly(ethylene glycol) (PEG) were esterified to synthesize a hydrophilic segment PEG-SS-COOH polymer containing a disulfide bond, and epsilon-caprolactone is ring-opened in Ar atmosphere to obtain a hydrophobic segment HO-PCL-OH homopolymer. The PEG-SS-PCL-SS-PEG triblock polymers were prepared by reacting the two in a certain ratio, and spontaneously assembled into micelles in an aqueous solution. Ag/AgO/CMCS composite hydrogels with a pH and redox dual-responsive were prepared by dispersing aspirin-loaded micelles into an Ag/AgO/CMCS hydrogel network loaded with another hydrophilic drug ciprofloxacin hydrochloride (CIP). The results showed that the micelles had redox sensitivity due to the insertion of disulfide bonds, and had certain stability within 24 h without reducing substances.In vitrosimulated drug release test of composite hydrogel showed that the hydrogel network swelled or degraded, the micelles were lysed, and the release of the drug was triggered when the composite hydrogels were exposed to the micro-environment with high pH or high DTT concentration. Therefore, this composite hydrogel could potentially be one of the candidate materials for the dual drug delivery system.

引用

页码：1706 / 1721

页数：16

共 38 条

[1] Dual crosslinked chondroitin sulfate injectable hydrogel formed via continuous Diels-Alder (DA) click chemistry for bone repair [J].

Bai, Xiao ;

Lu, Shaoyu ;

Cao, Zhen ;

Ni, Boli ;

Wang, Xin ;

Ning, Piao ;

Ma, Dongyang ;

Wei, Hua ;

Liu, Mingzhu .

CARBOHYDRATE POLYMERS, 2017, 166 :123-130

[2] Using Hydrogel to Diversify the Adaptability and Applicability of Functional Nanoparticles: From Nanotech-Flavored Jellies to Artificial Enzymes [J].

Cheng, Chongling ;

Zhang, Chuan ;

Wang, Dayang .

LANGMUIR, 2019, 35 (26) :8612-8628

[3] An injectable, dual pH and oxidation-responsive supramolecular hydrogel for controlled dual drug delivery [J].

Cheng, Xinfeng ;

Jin, Yong ;

Sun, Tongbing ;

Qi, Rui ;

Li, Hanping ;

Fan, Wuhou .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2016, 141 :44-52

[4] Biodegradable pH/temperature-sensitive oligo(β-amino ester urethane) hydrogels for controlled release of doxorubicin [J].

Cong Truc Huynh ;

Minh Khanh Nguyen ;

Lee, Doo Sung .

ACTA BIOMATERIALIA, 2011, 7 (08) :3123-3130

[5] Smart Hydrogel of Carboxymethyl Cellulose Grafted Carboxymethyl Polyvinyl Alcohol and Properties Studied for Future Material Applications [J].

Dahlan, Nuraina Anisa ;

Pushpamalar, Janarthanan ;

Veeramachineni, Anand Kumar ;

Muniyandy, Saravanan .

JOURNAL OF POLYMERS AND THE ENVIRONMENT, 2018, 26 (05) :2061-2071

[6]

Ding SY, 2016, NAT REV MATER, V1, DOI [10.1038/natrevmats.2016.71, 10.1038/natrevmats.2016.21]

[7] Self-assembled biodegradable micelles based on star-shaped PCL-b-PEG copolymers for chemotherapeutic drug delivery [J].

Dong, PengWei ;

Wang, XiuHong ;

Gu, YingChun ;

Wang, YuJun ;

Wang, YingJing ;

Gong, ChangYang ;

Luo, Feng ;

Guo, Gang ;

Zhao, Xia ;

Wei, YuQuan ;

Qian, ZhiYong .

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2010, 358 (1-3) :128-134

[8] In vitro and in vivo biocompatibility of dextran dialdehyde cross-linked gelatin hydrogel films [J].

Draye, JP ;

Delaey, B ;

Van de Voorde, A ;

Van Den Bulcke, A ;

De Reu, B ;

Schacht, E .

BIOMATERIALS, 1998, 19 (18) :1677-1687

[9] PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application [J].

Grossen, Philip ;

Witzigmann, Dominik ;

Sieber, Sandro ;

Huwyler, Jorg .

JOURNAL OF CONTROLLED RELEASE, 2017, 260 :46-60

[10] Smart Hydrogel-Based Biochemical Microsensor Array for Medical Diagnostics [J].

Guenther, M. ;

Gerlach, G. ;

Wallmersperger, T. ;

Avula, M. N. ;

Cho, S. H. ;

Xie, X. ;

Devener, B. V. ;

Solzbacher, F. ;

Tathireddy, P. ;

Magda, J. J. ;

Scholz, C. ;

Obeid, R. ;

Armstrong, T. .

WEARABLE/WIRELESS BODY SENSOR NETWORKS FOR HEALTHCARE APPLICATIONS, 2013, 85 :47-+

← 1 2 3 4 →