Non-Uniform-Sampling Ultrahigh Resolution TOCSY NMR: Analysis of Complex Mixtures at Microgram Levels

被引：24

作者：

Kakita, Veera M. R. ^{[1
]}

Hosur, Ramakrishna V. ^{[1
,2
]}

机构：

[1] UM DAE Ctr Excellence Basic Sci, Mumbai Univ Campus, Bombay 400098, Maharashtra, India

[2] Tata Inst Fundamental Res, Dept Chem Sci, 1 Homi Bhabha Rd, Bombay 400005, Maharashtra, India

来源：

CHEMPHYSCHEM | 2016年 / 17卷 / 15期

关键词：

fast screening; homodecoupling; indirect covariance processing; micromolar concentrations; non-uniform sampling; HOMONUCLEAR BROAD-BAND; PURE SHIFT NMR; MAXIMUM-ENTROPY RECONSTRUCTION; TRIPLE-RESONANCE SPECTRA; MULTIDIMENSIONAL NMR; PRECISE DETERMINATION; COUPLING-CONSTANTS; TIME-REVERSAL; H-1; SPECTRA; SPECTROSCOPY;

D O I：

10.1002/cphc.201600255

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Non-uniform sampling in combination with homonuclear broadband decoupling along an indirect dimension, and indirect covariance processing are used to record ultrahigh resolution two-dimensional TOCSY spectra in less than half an hour, for typical sample concentrations in the mm range. TOCSY correlations belonging to protons separated by as little as approximate to 2Hz can be distinctly discerned. The utility of the technique for low concentrations has been demonstrated.

引用

页码：2304 / 2308

页数：5

共 107 条

[21] 13C-detected NMR experiments for automatic resonance assignment of IDPs and multiple-fixing SMFT processing [J].