Type 1 interferons as a potential treatment against COVID-19

被引：350
作者：
Sallard, Erwan [1 ]
Lescure, Francois-Xavier [2 ,3 ]
Yazdanpanah, Yazdan [2 ,3 ]
Mentre, France [2 ]
Peiffer-Smadja, Nathan [2 ,3 ]
机构：
[1] Ecole Normale Super Paris, 45 Rue Ulm, F-75005 Paris, France
[2] Univ Paris, INSERM, IAME, F-75018 Paris, France
[3] Bichat Claude Bernard Univ Hosp, AP HP, Dept Infect & Trop Dis, 46 Rue Henri Huchard, F-75018 Paris, France
来源：
ANTIVIRAL RESEARCH | 2020年 / 178卷
关键词：
Interferon; COVID-19; SARS-CoV-2; RESPIRATORY SYNDROME CORONAVIRUS; SARS-CORONAVIRUS; SYNERGISTICALLY INHIBIT; BETA; RIBAVIRIN; REPLICATION; INFECTION; RESPONSES; MODEL;
D O I：
10.1016/j.antiviral.2020.104791
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Type 1 interferons have a broad antiviral activity in vitro and are currently evaluated in a clinical trial to treat MERS-CoV. In this review, we discuss preliminary data concerning the potential activity of type 1 interferons on SARS-CoV-2, and the relevance of evaluating these molecules in clinical trials for the treatment of COVID-19.
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页数：4
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