Type 1 interferons as a potential treatment against COVID-19

被引：351

作者：

Sallard, Erwan ^{[1
]}

Lescure, Francois-Xavier ^{[2
,3
]}

Yazdanpanah, Yazdan ^{[2
,3
]}

Mentre, France ^{[2
]}

Peiffer-Smadja, Nathan ^{[2
,3
]}

机构：

[1] Ecole Normale Super Paris, 45 Rue Ulm, F-75005 Paris, France

[2] Univ Paris, INSERM, IAME, F-75018 Paris, France

[3] Bichat Claude Bernard Univ Hosp, AP HP, Dept Infect & Trop Dis, 46 Rue Henri Huchard, F-75018 Paris, France

来源：

ANTIVIRAL RESEARCH | 2020年 / 178卷

关键词：

Interferon; COVID-19; SARS-CoV-2; RESPIRATORY SYNDROME CORONAVIRUS; SARS-CORONAVIRUS; SYNERGISTICALLY INHIBIT; BETA; RIBAVIRIN; REPLICATION; INFECTION; RESPONSES; MODEL;

D O I：

10.1016/j.antiviral.2020.104791

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Type 1 interferons have a broad antiviral activity in vitro and are currently evaluated in a clinical trial to treat MERS-CoV. In this review, we discuss preliminary data concerning the potential activity of type 1 interferons on SARS-CoV-2, and the relevance of evaluating these molecules in clinical trials for the treatment of COVID-19.

引用

页数：4

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