Bacterial subversion of host actin dynamics at the plasma membrane

被引：44

作者：

Carabeo, Rey ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Ctr Mol Microbiol & Infect, Div Cell & Mol Biol, London, England

来源：

CELLULAR MICROBIOLOGY | 2011年 / 13卷 / 10期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

ESCHERICHIA-COLI TIR; N-WASP; PEDESTAL FORMATION; ARP2/3; COMPLEX; SIGNALING PATHWAYS; MEDIATES INVASION; TYROSINE KINASES; EPITHELIAL-CELLS; MAMMALIAN-CELLS; EFFECTORS TIR;

D O I：

10.1111/j.1462-5822.2011.01651.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Invasion of non-phagocytic cells by a number of bacterial pathogens involves the subversion of the actin cytoskeletal remodelling machinery to produce actin-rich cell surface projections designed to engulf the bacteria. The signalling that occurs to induce these actin-rich structures has considerable overlap among a diverse group of bacteria. The molecular organization within these structures act in concert to internalize the invading pathogen. This dynamic process could be subdivided into three acts - actin recruitment, engulfment, and finally, actin disassembly/internalization. This review will present the current state of knowledge of the molecular processes involved in each stage of bacterial invasion, and provide a perspective that highlights the temporal and spatial control of actin remodelling that occurs during bacterial invasion.

引用

页码：1460 / 1469

页数：10

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