ONE-POT MULTI-COMPONENT SYNTHESIS OF THIOBARBITURICACID INVOLVED ULTRA SHORT ACTINGBARBITURATES AS SEDATIVE AND HYPNOTICS

被引：0

作者：

Deepa, M. ^{[1
]}

Srinivasan, M. ^{[1
]}

Vijayakumar, V. ^{[1
]}

Aarthi, A. ^{[1
]}

机构：

[1] Dhanalakshmi Srinivasan Coll Arts & Sci Women Aut, Perambalur 621212, Tamil Nadu, India

来源：

INTERNATIONAL JOURNAL OF LIFE SCIENCE AND PHARMA RESEARCH | 2021年

关键词：

Barbit; Anticonvulsants TLC; FT-IR; C-13; NMR; Thiobarbituric acid; SOLVENT-FREE CONDITIONS; MOLECULAR-SIEVES; IMINES; EFFICIENT; CONDENSATION; ALDEHYDES; CATALYST;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Barbituric acid synthesized novel bio-active Thiobarbituric acidanalogues.The synthesis sequence followed conventional organic syntheticprotocol.To screen different metal chlorides for catalystperformance.To be report here a simple but effective procedure for the synthesis of 2- iminothiobarbituric acid analogues via Schiff base multi-component condensation reaction.Monitoring the completion of reaction with the help of TLC (Thin- layer chromatography)technique.To be characterize the final product by FT-IR (Fourier-transform infrared spectroscopy), H-1 NMR (Proton nuclear magnetic resonance), and C-13 NMR (Carbon-13 nuclear magnetic resonance) spectralanalysis. Thefurtherantifungalstudiesofsynthesizedcompoundsagainstfungal strains.

引用

页码：151 / 159

页数：9

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